Tomlinson Mark, Rotheram-Borus Mary Jane, le Roux Ingrid M, Youssef Maryann, Nelson Sandahl H, Scheffler Aaron, Weiss Robert E, O'Connor Mary, Worthman Carol M
Department of Psychology, Stellenbosch University, Private Bag X1, Matieland, 7602, South Africa.
Department of Psychiatry and Biobehavioral Sciences, Semel Institute, University of California at Los Angeles, 10920 Wilshire Blvd., Suite 350, Los Angeles, CA, 90024, USA.
Prev Sci. 2016 Nov;17(8):937-948. doi: 10.1007/s11121-016-0676-x.
Almost all pregnant women (98 %) in 24 Cape Town neighborhoods were randomized by neighborhood to (1) the standard care (SC) condition (n = 12 neighborhoods; n = 594 pregnant women) or (2) the Philani Intervention Program (PIP) in which home visits by Community Health Workers (CHW) were conducted (n = 12 neighborhoods; n = 644 pregnant women). At 36 months post-birth (84.6 % follow-up), PIP mothers were significantly less depressed compared to the SC mothers. Children in PIP were significantly less likely to be stunted (24.3 vs 18.1 %, p = 0.013), to have better vocabularies, and were less likely to be hospitalized than children in the SC condition. These data suggest home visits may need to continue for several years post-birth. Sustainable, scalable perinatal intervention models are needed in LMIC.
在开普敦的24个社区中,几乎所有孕妇(98%)都按社区随机分为:(1)标准护理(SC)组(n = 12个社区;n = 594名孕妇),或(2)菲拉尼干预项目(PIP)组,即由社区卫生工作者(CHW)进行家访(n = 12个社区;n = 644名孕妇)。在产后36个月(随访率84.6%)时,与SC组母亲相比,PIP组母亲的抑郁程度明显更低。与SC组的儿童相比,PIP组的儿童发育迟缓的可能性显著降低(24.3%对18.1%,p = 0.013),词汇量更好,住院的可能性也更小。这些数据表明,家访可能需要在产后持续数年。低收入和中等收入国家需要可持续、可扩展的围产期干预模式。