Danchev N, Rusakov D
Eksp Med Morfol. 1989;28(1):23-8.
Neuropharmacological study was undertaken on the preparations viloxazine (emovit "Phafmachim" People's Republic of Bulgaria) and mianserin (lerivon "Organon" Holand). Comparative experiments were performed with chlorimipramine ("Spofa", CSSR). The behaviour of mice was evaluated by the test "haloperidol catalepsy" after acute and chronic administration of aforementioned antidepressants. Effects of the preparations were also investigated on the background of hypothermia and stereotypy, induced by apomorphine. The influence of antidepressants after acute and chronic (7 and 14 days) administration was studied on serotonin effect in the central nervous system by examining the influence of the preparations on tics of the head, induced by 5-hydroxytryptophan in mice. An analysis was made on the spectrum of action of the preparations on mediator systems of central nervous system and it was established that after chronic application of mianserin together with its serotoninolytic properties there were effects on adrenergic systems of the central nervous system as well.
对维洛沙嗪（保加利亚人民共和国“Phafmachim”公司的埃莫维特）和米安色林（荷兰“Organon”公司的莱立凡）制剂进行了神经药理学研究。与氯米帕明（捷克斯洛伐克社会主义共和国“Spofa”公司产品）进行了对比实验。在急性和慢性给予上述抗抑郁药后，通过“氟哌啶醇致僵”试验评估小鼠的行为。还研究了在阿扑吗啡诱导的体温过低和刻板行为背景下这些制剂的作用。通过检查制剂对小鼠5-羟色氨酸诱导的头部抽搐的影响，研究了急性和慢性（7天和14天）给予抗抑郁药后对中枢神经系统中血清素作用的影响。对这些制剂在中枢神经系统介质系统上的作用谱进行了分析，结果表明，在长期应用米安色林后，除了其血清素分解特性外，对中枢神经系统的肾上腺素能系统也有作用。
