a University of Iowa , Children's Hospital , Iowa City , IA , USA.
b Life Sciences Institute, University of Michigan , Ann Arbor , MI , USA.
Autophagy. 2016 Sep;12(9):1429-30. doi: 10.1080/15548627.2016.1203489. Epub 2016 Jul 20.
Two topics that have attracted recent attention in the field of autophagy concern the source of the membrane that is used to form the autophagosome during macroautophagy and the role of noncanonical autophagic pathways. The 2 topics may converge when considering the intersection of autophagy with viral infection. We suggest that noncanonical autophagy, which is sensitive to treatment with brefeldin A, may converge with the infectious cycles of certain DNA and RNA viruses that utilize membrane from the ER and cis-Golgi.
两个最近在自噬领域引起关注的话题涉及巨自噬过程中用于形成自噬体的膜的来源以及非典型自噬途径的作用。当考虑自噬与病毒感染的交叉时，这两个话题可能会交汇。我们认为，对布雷菲德菌素 A 敏感的非典型自噬可能与某些利用内质网和顺式高尔基体膜的 DNA 和 RNA 病毒的感染周期相交汇。
