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氨基甲酰谷氨酸可防止苯甲酸钠增强氨的毒性。

Carbamyl glutamate prevents the potentiation of ammonia toxicity by sodium benzoate.

作者信息

O'Connor J E, Costell M, Grisolía S

机构信息

Instituto de Investigaciones Citológicas de la Caja de Ahorros de Valencia, Spain.

出版信息

Eur J Pediatr. 1989 Apr;148(6):540-2. doi: 10.1007/BF00441553.

DOI:10.1007/BF00441553
PMID:2744016
Abstract

Sodium benzoate has been recommended for the treatment of hyperammonaemia in humans. However, benzoate potentiates ammonia toxicity and reduces urea synthesis in vitro and in vivo by decreasing the intramitochondrial levels of N-acetyl glutamate. Pretreatment of mice with carbamyl glutamate, a structural analogue of N-acetyl glutamate, decreases mortality induced by ammonium acetate and sodium benzoate administration. The protective effect of carbamyl glutamate is accompanied by an increase in urea production and of carbamyl phosphate synthetase activity.

摘要

苯甲酸钠已被推荐用于治疗人类高氨血症。然而，苯甲酸盐在体外和体内会增强氨毒性并通过降低线粒体内N-乙酰谷氨酸水平来减少尿素合成。用N-乙酰谷氨酸的结构类似物氨甲酰谷氨酸对小鼠进行预处理，可降低由给予乙酸铵和苯甲酸钠所诱导的死亡率。氨甲酰谷氨酸的保护作用伴随着尿素生成增加和氨甲酰磷酸合成酶活性增加。

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1
Carbamyl glutamate prevents the potentiation of ammonia toxicity by sodium benzoate.氨基甲酰谷氨酸可防止苯甲酸钠增强氨的毒性。
Eur J Pediatr. 1989 Apr;148(6):540-2. doi: 10.1007/BF00441553.
2
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引用本文的文献

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N-acetylglutamate synthase deficiency: an insight into the genetics, epidemiology, pathophysiology, and treatment.N-乙酰谷氨酸合成酶缺乏症：对遗传学、流行病学、病理生理学及治疗的深入了解
Appl Clin Genet. 2011 Aug 24;4:127-35. doi: 10.2147/TACG.S12702. Print 2011.
2
N-acetylglutamate synthase: structure, function and defects.N-乙酰谷氨酸合酶：结构、功能与缺陷
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Ammonia intoxication in rats: protection by N-carbamoyl-L-glutamate plus L-arginine.大鼠氨中毒：N-氨甲酰-L-谷氨酸加L-精氨酸的保护作用
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Acute and chronic effects of carbamyl glutamate on blood urea and ammonia.
Eur J Pediatr. 1985 Jan;143(3):196-7. doi: 10.1007/BF00442137.
10
The effect of sodium benzoate on ammonia toxicity in rats.
Biochem Biophys Res Commun. 1986 Jul 16;138(1):369-73. doi: 10.1016/0006-291x(86)90290-1.