Weber-Gerlach Michaela, Weber Friedemann
Laboratory of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan.
Institute for Virology, FB10-Veterinary Medicine, Justus Liebig University, Giessen, Germany
J Virol. 2016 Sep 12;90(19):8389-94. doi: 10.1128/JVI.00041-16. Print 2016 Oct 1.
The nonstructural protein NS1 is well established as a virulence factor of influenza A virus counteracting induction of the antiviral type I interferon system. Recent studies now show that viral structural proteins, their derivatives, and even the genome itself also contribute to keeping the host defense under control. Here, we summarize the current knowledge on these NS1-independent interferon escape strategies.
非结构蛋白NS1作为甲型流感病毒的一种毒力因子，能够对抗抗病毒I型干扰素系统的诱导，这一点已得到充分证实。最近的研究表明，病毒结构蛋白、其衍生物，甚至病毒基因组本身也有助于控制宿主防御。在此，我们总结了目前关于这些不依赖NS1的干扰素逃逸策略的知识。
