甲型流感病毒NS1蛋白在抗病毒防御中的功能。
Functions of the influenza A virus NS1 protein in antiviral defense.
作者信息
Krug Robert M
机构信息
Department of Molecular Biosciences, Center for Infectious Disease, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX, USA.
出版信息
Curr Opin Virol. 2015 Jun;12:1-6. doi: 10.1016/j.coviro.2015.01.007. Epub 2015 Jan 29.
Abstract
Influenza A viruses counteract host antiviral activities, especially the production of interferons (IFNs) and the activities of IFN-induced proteins that inhibit virus replication. The viral NS1 protein is largely responsible for countering these IFN antiviral responses, but there are functional differences between the NS1 proteins of different virus strains. The NS1 protein inhibits IFN production by two mechanisms: inhibition of the activation of IRF3 and IFN transcription; and inhibition of the processing of IFN pre-mRNAs. The NS1 proteins of several virus strains do not inhibit IRF3 activation, and the NS1 protein of one virus strain does not inhibit the processing of IFN pre-mRNAs. Many issues remain concerning the mechanisms of action of the various NS1 proteins in countering the IFN response.
摘要
甲型流感病毒会对抗宿主的抗病毒活性，尤其是干扰素（IFN）的产生以及抑制病毒复制的IFN诱导蛋白的活性。病毒的NS1蛋白在很大程度上负责对抗这些IFN抗病毒反应，但不同病毒株的NS1蛋白存在功能差异。NS1蛋白通过两种机制抑制IFN的产生：抑制IRF3的激活和IFN转录；以及抑制IFN前体mRNA的加工。几种病毒株的NS1蛋白不抑制IRF3的激活，而一种病毒株的NS1蛋白不抑制IFN前体mRNA的加工。关于各种NS1蛋白对抗IFN反应的作用机制，仍有许多问题存在。
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