立体定向体部放射治疗（SBRT）时代的放射增敏机遇。
Opportunities for Radiosensitization in the Stereotactic Body Radiation Therapy (SBRT) Era.
作者信息
Moding Everett J, Mowery Yvonne M, Kirsch David G
机构信息
From the *Department of Radiation Oncology, Duke University, Durham; †Department of Internal Medicine, Moses H. Cone Memorial Hospital, Greensboro; and ‡Department of Pharmacology & Cancer Biology, Duke University, Durham, NC.
出版信息
Cancer J. 2016 Jul-Aug;22(4):267-73. doi: 10.1097/PPO.0000000000000203.
Abstract
Stereotactic body radiation therapy (SBRT) utilizing a small number of high-dose radiation therapy fractions continues to expand in clinical application. Although many approaches have been proposed to radiosensitize tumors with conventional fractionation, how these radiosensitizers will translate to SBRT remains largely unknown. Here, we review our current understanding of how SBRT eradicates tumors, including the potential contributions of endothelial cell death and immune system activation. In addition, we identify several new opportunities for radiosensitization generated by the move toward high dose per fraction radiation therapy.
摘要
利用少量高剂量放疗分次的立体定向体部放疗（SBRT）在临床应用中持续扩展。尽管已经提出了许多用传统分次放疗使肿瘤放射增敏的方法，但这些放射增敏剂如何转化应用于SBRT在很大程度上仍不清楚。在此，我们综述了目前对SBRT如何根除肿瘤的理解，包括内皮细胞死亡和免疫系统激活的潜在作用。此外，我们还确定了向高剂量每次分割放疗转变所带来的几个放射增敏新机会。
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