Caspi E, Ron-El R, Golan A, Herman A, Nachum H
Department of Obstetrics and Gynecology, Assaf Harofe Medical Centre, Zerifin, Israel.
Fertil Steril. 1989 Jul;52(1):146-8. doi: 10.1016/s0015-0282(16)60804-x.
The timing of ET was evaluated by transferring four embryos at 44 to 48 hours, 68 to 72 hours, or equally dividing and sequentially transferring at 44 to 48 and 68 to 72 hours after insemination. Fifty-one patients were randomly allocated to one of the above protocols. The mean number of blastomeres of embryos transferred at 68 to 72 hours after insemination was significantly (P less than 0.0001) higher than those transferred at 44 to 48 hours. The number of embryos with good morphology was similar in all study groups. The pregnancy rate was similar in the three protocol groups, 53% at 44 to 48 hours, 59% at 64 to 72 hours, and 47% by sequential transfer. There probably is no advantage in delaying the transfer or dividing the embryos into two sequential transfers. It seems that sequential transfer is not associated with any harmful effect.
通过在授精后44至48小时、68至72小时移植4个胚胎，或在44至48小时和68至72小时将胚胎均分为两份并依次移植来评估胚胎移植（ET）的时机。51例患者被随机分配至上述方案之一。授精后68至72小时移植的胚胎的卵裂球平均数显著高于（P<0.0001）44至48小时移植的胚胎。所有研究组中形态良好的胚胎数量相似。三个方案组的妊娠率相似，44至48小时组为53%，64至72小时组为59%，序贯移植组为47%。延迟移植或将胚胎分为两次序贯移植可能并无优势。似乎序贯移植不会产生任何有害影响。
