Zhang Tian-Ping, Li Hong-Miao, Leng Rui-Xue, Li Xiang-Pei, Li Xiao-Mei, Pan Hai-Feng, Ye Dong-Qing
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China; Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis, Hefei, China.
Department of Rheumatology, Anhui Provincial Hospital, Hefei, China.
Cytokine. 2016 Oct;86:15-20. doi: 10.1016/j.cyto.2016.07.008. Epub 2016 Jul 19.
To evaluate the plasma levels of six adipokines, including chemerin, omentin-1, lipocalin-2, cathepsin-S, cathepsin-L and adipsin, in patients with SLE.
Ninety SLE patients and ninety control subjects were recruited, plasma adipokines levels were measured by enzyme-linked immunosorbent assay, and their associations with major clinical and laboratory indexes were analyzed.
There were no significant differences in plasma chemerin, omentin-1, lipocalin-2, cathepsin-S, cathepsin-L and adipsin levels between SLE patients and controls. Further subgroup analyses by major clinical and laboratory indexes showed that plasma omentin-1 level was significantly lower in SLE patients without nephritis when compared with those patients with nephritis (P=0.002). Plasma chemerin, cathepsin-S levels in SLE patients without nervous system disorder were significantly lower in comparison with SLE patients with nervous system disorder (P=0.035, P=0.029). No significant associations of other adipokines with any major clinical and laboratory indexes were observed.
Plasma levels of chemerin, omentin-1, lipocalin-2, cathepsin-S, cathepsin-L and adipsin in SLE patients were not markedly different from the normal controls. The presence of nephritis was connected with higher plasma omentin-1 levels in SLE patients, and the presence of nervous system disorder was associated with higher plasma chemerin, cathepsin-S levels in SLE patients. However, functional studies are awaited to further explore the potential roles of these cytokines in SLE.
评估系统性红斑狼疮（SLE）患者血浆中六种脂肪因子的水平，这六种脂肪因子包括chemerin、网膜素-1、lipocalin-2、组织蛋白酶-S、组织蛋白酶-L和脂肪酶。
招募90例SLE患者和90例对照者，采用酶联免疫吸附测定法检测血浆脂肪因子水平，并分析其与主要临床和实验室指标的相关性。
SLE患者与对照者血浆chemerin、网膜素-1、lipocalin-2、组织蛋白酶-S、组织蛋白酶-L和脂肪酶水平无显著差异。按主要临床和实验室指标进行的进一步亚组分析显示，无肾炎的SLE患者血浆网膜素-1水平显著低于有肾炎的患者（P = 0.002）。无神经系统疾病的SLE患者血浆chemerin、组织蛋白酶-S水平显著低于有神经系统疾病的SLE患者（P = 0.035，P = 0.029）。未观察到其他脂肪因子与任何主要临床和实验室指标有显著相关性。
SLE患者血浆chemerin、网膜素-1、lipocalin-2、组织蛋白酶-S、组织蛋白酶-L和脂肪酶水平与正常对照者无明显差异。肾炎的存在与SLE患者较高的血浆网膜素-1水平相关，神经系统疾病的存在与SLE患者较高的血浆chemerin、组织蛋白酶-S水平相关。然而，尚需功能研究进一步探索这些细胞因子在SLE中的潜在作用。
