Yilmaz Yusuf, Yonal Oya, Kurt Ramazan, Alahdab Yesim Ozen, Eren Fatih, Ozdogan Osman, Celikel Cigdem Ataizi, Imeryuz Nese, Kalayci Cem, Avsar Erol
Department of Gastroenterology, Marmara University School of Medicine, Altunizade, Istanbul, Turkey.
Scand J Gastroenterol. 2011 Jan;46(1):91-7. doi: 10.3109/00365521.2010.516452. Epub 2010 Sep 1.
The novel adipokines omentin, chemerin, and adipsin are associated with insulin resistance and the components of the metabolic syndrome. We assayed circulating levels of these molecules and examined their association with clinical, biochemical, and histological phenotypes in patients with nonalcoholic fatty liver disease (NAFLD).
Serum levels of omentin, chemerin, and adipsin were assayed by enzyme-linked immunosorbent assay in 99 patients with biopsy-proven NAFLD and 75 control subjects. We analyzed associations between adipokines and the characteristics of patients with NAFLD using multivariable linear regression models.
Adipsin levels did not differ between patients and controls, whereas both omentin and chemerin levels were significantly higher in patients with biopsy-proven NAFLD than in controls (both p values <0.001). Serum omentin levels were significantly associated with C-reactive protein (r = 0.29, p < 0.01) and the degree of hepatocyte ballooning (r = 0.27, p < 0.01), whereas chemerin showed a modest association with liver fibrosis (r = 0.22, p = 0.04). After stepwise linear regression analysis adjusting for potential confounders, serum omentin levels retained their independent significance as a predictor of hepatocyte ballooning in patients with NAFLD (β = 1.42; t = 2.79, p < 0.01).
Our results suggest that serum omentin levels are raised in patients with NAFLD regardless of potential confounders and represent an independent predictor of hepatocyte ballooning.
新型脂肪因子网膜素、趋化素和脂肪酶与胰岛素抵抗及代谢综合征的组成成分相关。我们检测了这些分子的循环水平，并研究了它们与非酒精性脂肪性肝病（NAFLD）患者的临床、生化和组织学表型之间的关联。
采用酶联免疫吸附测定法检测99例经活检证实为NAFLD的患者和75例对照者血清中网膜素、趋化素和脂肪酶的水平。我们使用多变量线性回归模型分析脂肪因子与NAFLD患者特征之间的关联。
患者和对照者的脂肪酶水平无差异，而经活检证实为NAFLD的患者的网膜素和趋化素水平均显著高于对照者（p值均<0.001）。血清网膜素水平与C反应蛋白显著相关（r = 0.29，p < 0.01），与肝细胞气球样变程度显著相关（r = 0.27，p < 0.01），而趋化素与肝纤维化有适度关联（r = 0.22，p = 0.04）。在对潜在混杂因素进行逐步线性回归分析后，血清网膜素水平作为NAFLD患者肝细胞气球样变的预测指标仍具有独立意义（β = 1.42；t = 2.79，p < 0.01）。
我们的结果表明，无论潜在混杂因素如何，NAFLD患者的血清网膜素水平均升高，且是肝细胞气球样变的独立预测指标。
