Yao Yongchao, Xu Deqiu, Zhu Yuhong, Dai Xin, Yu Yunlong, Luo Jianbin, Zhang Shiyong
National Engineering Research Center for Biomaterials, Sichuan University 29 Wangjiang Road Chengdu 610064 China
College of Chemistry and Environmental Protection Engineering, Southwest Minzu University Chengdu 610041 China
Chem Sci. 2019 Dec 3;11(3):757-762. doi: 10.1039/c9sc05741b.
Dandelion flower-like micelles (DFMs) were prepared by self-assembly of polycaprolactone (PCL) functionalized surface cross-linked micelles (SCMs). Upon reductive stimuli, the SCMs can be released from the DFMs by non-Brownian motion at an average speed of 19.09 μm s. Similar to the property of dandelion flowers dispersing their seeds over a long distance, the DFMs demonstrated enhanced multicellular tumor spheroid (MTS) penetration, a useful property in the treatment of many diseases including cancer, infection-of-biofilm diseases and ocular problems.
通过聚己内酯（PCL）功能化表面交联胶束（SCM）的自组装制备了蒲公英花状胶束（DFM）。在还原刺激下，SCM可以以19.09μm/s的平均速度通过非布朗运动从DFM中释放出来。类似于蒲公英花将种子远距离散播的特性，DFM表现出增强的多细胞肿瘤球体（MTS）穿透能力，这在治疗包括癌症、生物膜感染性疾病和眼部问题在内的许多疾病中是一种有用的特性。
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