Mueller-Eckhardt C, Becker T, Weisheit M, Witz C, Santoso S
Vox Sang. 1986;50(2):94-6. doi: 10.1111/j.1423-0410.1986.tb04853.x.
A case of neonatal alloimmune thrombocytopenia due to fetomaternal incompatibility against the platelet-specific antigen Zwb (PlA2) is described. The antibody was of the IgG class and did not fix complement in vitro. Its specificity was established by panel identification and by comparison to a Zwb antiserum. Gene dosage determinations of Zwa antigens on platelets of parents and child revealed that the mother was homozygous Zwa Zwa, while father and child were heterozygous for this antigen.
本文描述了一例因母婴血小板特异性抗原Zwb（PlA2）不相容导致的新生儿同种免疫性血小板减少症。该抗体为IgG类，在体外不固定补体。通过血小板分型鉴定并与Zwb抗血清比较确定了其特异性。对父母及患儿血小板上Zwa抗原的基因剂量测定显示，母亲为Zwa Zwa纯合子，而父亲和患儿为该抗原的杂合子。
