Stavrakis Thomas, Kalogiannidis Ioannis, Petousis Stamatios, Tsompanidou Chrisoula, Delkos Dimitris, Prapas Nikolaos, Rousso David
Third Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.
Department of Pathology, 'Agios Dimitrios' General Hospital, 54634 Thessaloniki, Greece.
Oncol Lett. 2016 Aug;12(2):1079-1082. doi: 10.3892/ol.2016.4695. Epub 2016 Jun 9.
Sertoli-Leydig cell tumors (SLCTs) are an uncommon subtype of sex-cord stromal tumors of the ovary, which most commonly arise in women of reproductive age, creating an issue with regard to the preservation of fertility. The clinical manifestation of SLCTs varies widely, ranging from an asymptomatic clinical profile to extreme virilization. Correct diagnosis of SLCT is crucial and is primarily based on histopathological results. The current study presents the case of a 20-year-old woman who underwent unilateral salpingo-oophorectomy and adjuvant chemotherapy due to the diagnosis of an SLCT of the left ovary. Almost 2 years after the initial surgery, during the follow-up period, the patient conceived normally. Pregnancy was uneventful and the patient vaginally delivered a healthy infant at 38 weeks of gestation. A total of 1 year after delivery (3 years after the initial diagnosis), follow-up of the patient did not reveal any disease recurrence. In conclusion, SLCTs may be adequately treated by fertility-sparing surgery and chemotherapy in young women who wish to preserve their fertility. Natural conception, an uncomplicated pregnancy and a vaginal delivery are possible.
支持细胞-间质细胞瘤(SLCTs)是卵巢性索间质肿瘤中一种罕见的亚型,最常见于育龄女性,这就产生了生育力保留方面的问题。SLCTs的临床表现差异很大,从无症状的临床特征到极度男性化。SLCT的正确诊断至关重要,主要基于组织病理学结果。本研究报告了一名20岁女性的病例,该女性因诊断为左卵巢SLCT而接受了单侧输卵管卵巢切除术及辅助化疗。初次手术后近2年,在随访期间,患者正常受孕。妊娠过程顺利,患者在妊娠38周时经阴道分娩了一名健康婴儿。分娩后1年(初次诊断后3年),对该患者的随访未发现任何疾病复发。总之,对于希望保留生育力的年轻女性,SLCTs可通过保留生育功能的手术和化疗得到充分治疗。自然受孕、妊娠过程无并发症及经阴道分娩都是可能的。