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Oncol Lett. 2016 Aug;12(2):1079-1082. doi: 10.3892/ol.2016.4695. Epub 2016 Jun 9.
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Does surgery to preserve fertility in Sertoli-Leydig cell tumours increase the likelihood of spontaneous conception?行保留生育功能手术能否增加支持-间质细胞瘤自发性妊娠的可能性?
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本文引用的文献

1
Sertoli-Leydig cell tumors: current status of surgical management: literature review and proposal of treatment.支持细胞瘤-间质细胞瘤:手术治疗的现状:文献回顾与治疗建议。
Gynecol Endocrinol. 2013 May;29(5):412-7. doi: 10.3109/09513590.2012.754878. Epub 2013 Feb 4.
2
A clinicopathological analysis of 40 cases of ovarian Sertoli-Leydig cell tumors.40 例卵巢支持-间质细胞瘤的临床病理分析。
Gynecol Oncol. 2012 Nov;127(2):384-9. doi: 10.1016/j.ygyno.2012.07.114. Epub 2012 Jul 28.
3
Ovarian Sertoli-Leydig cell tumors. a retrospective MITO study.卵巢支持-间质细胞瘤。一项 MITO 的回顾性研究。
Gynecol Oncol. 2012 Jun;125(3):673-6. doi: 10.1016/j.ygyno.2012.03.024. Epub 2012 Mar 22.
4
DICER1 syndrome: clarifying the diagnosis, clinical features and management implications of a pleiotropic tumour predisposition syndrome.DICER1 综合征:阐明一种多效性肿瘤易感性综合征的诊断、临床特征和管理意义。
J Med Genet. 2011 Apr;48(4):273-8. doi: 10.1136/jmg.2010.083790. Epub 2011 Jan 25.
5
DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors.家族性多发性结节性甲状腺肿伴和不伴卵巢 Sertoli-Leydig 细胞瘤中 DICER1 突变。
JAMA. 2011 Jan 5;305(1):68-77. doi: 10.1001/jama.2010.1910.
6
Virilising ovarian tumour: a case associating a Sertoli-Leydig cell tumour and a Brenner tumour.男性化卵巢肿瘤:一例 Sertoli-Leydig 细胞瘤和 Brenner 瘤合并病例。
Gynecol Endocrinol. 2011 May;27(5):345-50. doi: 10.3109/09513590.2010.492883. Epub 2010 Jun 23.
7
Mucinous adenocarcinoma as heterologous element in intermediately differentiated Sertoli-Leydig cell tumor of the ovary.卵巢中分化 Sertoli-Leydig 细胞肿瘤中的异源性黏液性腺癌成分。
Pathol Res Pract. 2010 Jul 15;206(7):489-92. doi: 10.1016/j.prp.2009.07.012. Epub 2009 Aug 11.
8
Patterns of metastasis in sex cord-stromal tumors of the ovary: can routine staging lymphadenectomy be omitted?卵巢性索间质肿瘤的转移模式:常规分期淋巴结切除术可省略吗?
Gynecol Oncol. 2009 Apr;113(1):86-90. doi: 10.1016/j.ygyno.2008.12.007. Epub 2009 Jan 21.
9
Sertoli-Leydig cell tumor: a rare ovarian neoplasm. Case report and review of literature.支持-间质细胞瘤:一种罕见的卵巢肿瘤。病例报告及文献复习
Gynecol Endocrinol. 2008 Apr;24(4):230-4. doi: 10.1080/09513590801953465.
10
Use of novel serum markers in clinical follow-up of Sertoli-Leydig cell tumours.新型血清标志物在支持间质细胞瘤临床随访中的应用
Clin Chem Lab Med. 2007;45(5):657-61. doi: 10.1515/CCLM.2007.120.

一名20岁卵巢支持-间质细胞瘤患者的保留生育功能管理及产科结局:病例报告并文献复习

Fertility-sparing management and obstetric outcomes in a 20-year-old patient with a Sertoli-Leydig cell tumor of the ovary: A case report and review of the literature.

作者信息

Stavrakis Thomas, Kalogiannidis Ioannis, Petousis Stamatios, Tsompanidou Chrisoula, Delkos Dimitris, Prapas Nikolaos, Rousso David

机构信息

Third Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.

Department of Pathology, 'Agios Dimitrios' General Hospital, 54634 Thessaloniki, Greece.

出版信息

Oncol Lett. 2016 Aug;12(2):1079-1082. doi: 10.3892/ol.2016.4695. Epub 2016 Jun 9.

DOI:10.3892/ol.2016.4695
PMID:27446397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4950529/
Abstract

Sertoli-Leydig cell tumors (SLCTs) are an uncommon subtype of sex-cord stromal tumors of the ovary, which most commonly arise in women of reproductive age, creating an issue with regard to the preservation of fertility. The clinical manifestation of SLCTs varies widely, ranging from an asymptomatic clinical profile to extreme virilization. Correct diagnosis of SLCT is crucial and is primarily based on histopathological results. The current study presents the case of a 20-year-old woman who underwent unilateral salpingo-oophorectomy and adjuvant chemotherapy due to the diagnosis of an SLCT of the left ovary. Almost 2 years after the initial surgery, during the follow-up period, the patient conceived normally. Pregnancy was uneventful and the patient vaginally delivered a healthy infant at 38 weeks of gestation. A total of 1 year after delivery (3 years after the initial diagnosis), follow-up of the patient did not reveal any disease recurrence. In conclusion, SLCTs may be adequately treated by fertility-sparing surgery and chemotherapy in young women who wish to preserve their fertility. Natural conception, an uncomplicated pregnancy and a vaginal delivery are possible.

摘要

支持细胞-间质细胞瘤(SLCTs)是卵巢性索间质肿瘤中一种罕见的亚型,最常见于育龄女性,这就产生了生育力保留方面的问题。SLCTs的临床表现差异很大,从无症状的临床特征到极度男性化。SLCT的正确诊断至关重要,主要基于组织病理学结果。本研究报告了一名20岁女性的病例,该女性因诊断为左卵巢SLCT而接受了单侧输卵管卵巢切除术及辅助化疗。初次手术后近2年,在随访期间,患者正常受孕。妊娠过程顺利,患者在妊娠38周时经阴道分娩了一名健康婴儿。分娩后1年(初次诊断后3年),对该患者的随访未发现任何疾病复发。总之,对于希望保留生育力的年轻女性,SLCTs可通过保留生育功能的手术和化疗得到充分治疗。自然受孕、妊娠过程无并发症及经阴道分娩都是可能的。