Nishizumi M
Fukuoka Igaku Zasshi. 1989 May;80(5):235-9.
Two isomers of polychlorinated dibenzofurans, 2,3,4,7,8-pentachlorodibenzofuran or 1,2,3,4,7,8-hexachlorodibenzofuran, both of which are present in the yusho patients, were subcutaneously administered to rats in a single non-lethal dose to examine acute or subacute toxicity. Maximal inhibition of increase in body weight and decrease in daily locomotor activity were observed in the rats treated with 370 micrograms/kg of these compounds at 3 to 4 weeks after treatment, especially with 2,3,4,7,8-pentachlorodibenzofuran. Histopathologically, hypertrophy of the liver and atrophy of the thymus were noted at 4 weeks after treatment with this dose, while bile duct hyperplasia in the liver was observed at 40 weeks after treatment with 250 micrograms/kg of these compounds.
多氯二苯并呋喃的两种异构体，即2,3,4,7,8 - 五氯二苯并呋喃或1,2,3,4,7,8 - 六氯二苯并呋喃，这两种异构体均存在于油症患者体内，以单次非致死剂量皮下注射给大鼠，以检查急性或亚急性毒性。在用370微克/千克这些化合物处理的大鼠中，在处理后3至4周观察到体重增加的最大抑制和每日运动活动的减少，尤其是在用2,3,4,7,8 - 五氯二苯并呋喃处理的大鼠中。组织病理学上，用此剂量处理4周后可见肝脏肥大和胸腺萎缩，而在用250微克/千克这些化合物处理40周后观察到肝脏中的胆管增生。
