Nishizumi M
Department of Community Health Science, Saga Medical School.
Fukuoka Igaku Zasshi. 1991 May;82(5):246-50.
Previous studies showed that 2,3,4,7,8-pentachlorodibenzofuran (PenCDF) and 1,2,3,4,7,8-hexachlorodibenzofuran (HCDF) could produce tumors in the liver and subcutaneous tissues of rats by subcutaneous administration. The present study has examined the carcinogenicity of the same compounds in rats by oral administration. Wistar strain male rats were sacrificed at two years after oral administration (0.2 mg/rat) of 2,3,4,7,8-PenCDF or 1,2,3,4,7,8-HCDF. Among rats given 2,3,4,7,8-PenCDF, a cholangiohepatoma and a osteosarcoma were revealed in a rat each. Moreover, a few hepatic nodules were found in two rats in each experimental group. These results suggest that these compounds of polychlorinated dibenzofurans have a tumorigenic potency by oral administration.
先前的研究表明，2,3,4,7,8-五氯二苯并呋喃（PenCDF）和1,2,3,4,7,8-六氯二苯并呋喃（HCDF）通过皮下给药可在大鼠的肝脏和皮下组织中产生肿瘤。本研究通过口服给药检测了相同化合物在大鼠中的致癌性。在口服给予2,3,4,7,8-PenCDF或1,2,3,4,7,8-HCDF（0.2mg/只大鼠）两年后，处死Wistar品系雄性大鼠。在给予2,3,4,7,8-PenCDF的大鼠中，分别有一只大鼠出现胆管肝细胞瘤和骨肉瘤。此外，在每个实验组的两只大鼠中发现了一些肝结节。这些结果表明，这些多氯二苯并呋喃化合物通过口服给药具有致瘤潜能。
