Mount Sinai Hospital Centre for Inflammatory Bowel Disease, University of Toronto, Toronto, ON, Canada M5G 1X5.
Can J Gastroenterol Hepatol. 2016;2016:7857352. doi: 10.1155/2016/7857352. Epub 2016 Apr 21.
Introduction. Crohn's disease is most commonly found in the terminal ileum and colonic region. Magnetic resonance has become a useful modality for assessing small bowel activity. In this study, we performed a systematic review and meta-analysis on the use of MR in detecting small bowel activity as well as extramural complications in Crohn's patients. Methods. Two independent reviewers sorted through articles until October 2, 2014. We included both studies providing raw data for pooling and studies without raw data. Sensitivity, specificity, likelihood ratios, and 95% confidence intervals were calculated for each study. Results. There were 27 included studies, of which 19 were included in the pooled analysis. Pooled analysis of the 19 studies (1020 patients) with raw data revealed a sensitivity of 0.88 (95% CI 0.86 to 0.91) and specificity was 0.88 (95% CI 0.84 to 0.91). In regard to detecting stenosis, pooled sensitivity was 0.65 (95% CI 0.53 to 0.76) and specificity was 0.93 (95% CI 0.89 to 0.96). Conclusion. MR imaging provides a reliable alternative in detecting small bowel activity in patients with Crohn's disease. Its advantages include high diagnostic accuracy and no radiation exposure while its disadvantages include high cost and limited availability.
介绍。克罗恩病最常发生在末端回肠和结肠区域。磁共振成像已成为评估小肠活动的有用方法。在这项研究中，我们对磁共振成像在检测克罗恩病患者小肠活动和肠外并发症中的应用进行了系统评价和荟萃分析。
方法。两位独立的审查员对文章进行筛选，直到 2014 年 10 月 2 日。我们纳入了提供汇总数据的研究和没有汇总数据的研究。对每一项研究计算了敏感性、特异性、似然比和 95%置信区间。
结果。共纳入 27 项研究，其中 19 项研究纳入了汇总分析。对 19 项具有原始数据的研究（1020 例患者）进行汇总分析，敏感性为 0.88（95%可信区间 0.86 至 0.91），特异性为 0.88（95%可信区间 0.84 至 0.91）。在检测狭窄方面，汇总敏感性为 0.65（95%可信区间 0.53 至 0.76），特异性为 0.93（95%可信区间 0.89 至 0.96）。
结论。磁共振成像在检测克罗恩病患者的小肠活动方面提供了一种可靠的替代方法。其优点包括高诊断准确性和无辐射暴露，缺点包括高成本和可用性有限。
