Cambridge University Hospitals NHS Foundation Trust, The Rosie Hospital, The Evelyn Perinatal Imaging Centre, neoLAB, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, United Kingdom; Cambridge University Hospitals NHS Foundation Trust, The Rosie Hospital, Department of Neonatology, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, United Kingdom.
Cambridge University Hospitals NHS Foundation Trust, The Rosie Hospital, The Evelyn Perinatal Imaging Centre, neoLAB, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, United Kingdom; University College London, Department of Medical Physics and Biomedical Engineering, Malet Place Engineering Building, Gower Street, London WC1E 6BT, United Kingdom.
Neurophotonics. 2016 Jul;3(3):031408. doi: 10.1117/1.NPh.3.3.031408. Epub 2016 May 2.
Burst suppression (BS) is an electroencephalographic state associated with a profound inactivation of the brain. BS and pathological discontinuous electroencephalography (EEG) are often observed in term-age infants with neurological injury and can be indicative of a poor outcome and lifelong disability. Little is known about the neurophysiological mechanisms of BS or how the condition relates to the functional state of the neonatal brain. We used simultaneous EEG and diffuse optical tomography (DOT) to investigate whether bursts of EEG activity in infants with hypoxic ischemic encephalopathy are associated with an observable cerebral hemodynamic response. We were able to identify significant changes in concentration of both oxy and deoxyhemoglobin that are temporally correlated with EEG bursts and present a relatively consistent morphology across six infants. Furthermore, DOT reveals patient-specific spatial distributions of this hemodynamic response that may be indicative of a complex pattern of cortical activation underlying discontinuous EEG activity that is not readily apparent in scalp EEG.
爆发抑制（BS）是一种与大脑深度失活相关的脑电图状态。BS 和病理性间断性脑电图（EEG）在伴有神经损伤的足月婴儿中经常观察到，可能提示预后不良和终身残疾。BS 的神经生理机制或其与新生儿大脑功能状态的关系知之甚少。我们使用同时进行的脑电图和漫射光学断层扫描（DOT）来研究患有缺氧缺血性脑病的婴儿的脑电图活动爆发是否与可观察到的脑血流动力学反应有关。我们能够识别出与脑电图爆发具有时间相关性的氧合和脱氧血红蛋白浓度的显著变化，并在六名婴儿中呈现出相对一致的形态。此外，DOT 揭示了这种血流动力学反应的患者特异性空间分布，这可能表明间断性 EEG 活动背后存在复杂的皮质激活模式，而头皮 EEG 不易察觉。
