Zhang Pu, Wang Yi, Yin Yibing
College of Pharmacy, Chongqing Research Center for Pharmaceutical Engineering, Chongqing Medical University, Chongqing 400016, China.
Chongqing Key Laboratory of Green Synthesis and Applications, College of Chemistry, Chongqing Normal University, Chongqing 401331, China.
Sensors (Basel). 2016 Jul 20;16(7):1124. doi: 10.3390/s16071124.
In this work, we present a simple and rapid method to synthesize red luminescent gold nanoclusters (AuNCs) with high quantum yield (QY, ~16%), excellent photostability and biocompatibility. Next, we fabricated a solid membrane by loading the as-prepared AuNCs in an agar matrix. Different from nanomaterials dispersed in solution, the AuNCs-based solid membrane has distinct advantages including convenience of transportation, while still maintaining strong red luminescence, and relatively long duration storage without aggregation. Taking hydrogen peroxide (H₂O₂) as a typical example, we then employed the AuNCs as a luminescent probe and investigated their sensing performance, either in solution phase or on a solid substrate. The detection of H₂O₂ could be achieved in wide concentration ranges over 805 nM-1.61 mM and 161 μM-19.32 mM in solution and on a solid membrane, respectively, with limits of detection (LOD) of 80 nM and 20 μM. Moreover, the AuNCs-based membrane could also be used for visual detection of H₂O₂ in the range of 0-3.22 mM. In view of the convenient synthesis route and attractive luminescent properties, the AuNCs-based membrane presented in this work is quite promising for applications such as optical sensing, fluorescent imaging, and photovoltaics.
在这项工作中，我们提出了一种简单快速的方法来合成具有高量子产率（QY，约16%）、优异光稳定性和生物相容性的红色发光金纳米团簇（AuNCs）。接下来，我们通过将制备好的AuNCs负载在琼脂基质中来制备固体膜。与分散在溶液中的纳米材料不同，基于AuNCs的固体膜具有明显的优势，包括运输方便，同时仍保持强烈的红色发光，以及相对长时间储存而不聚集。以过氧化氢（H₂O₂）为例，我们随后将AuNCs用作发光探针，并研究了它们在溶液相或固体基质上的传感性能。在溶液中和固体膜上分别可以在805 nM - 1.61 mM和161 μM - 19.32 mM的宽浓度范围内检测H₂O₂，检测限（LOD）分别为80 nM和20 μM。此外，基于AuNCs的膜还可用于在0 - 3.22 mM范围内对H₂O₂进行可视化检测。鉴于其简便的合成路线和吸引人的发光特性，本文提出的基于AuNCs的膜在光学传感、荧光成像和光伏等应用方面颇具前景。
