Carducci Annalaura, Donzelli Gabriele, Cioni Lorenzo, Verani Marco
Laboratory of Hygiene and Environmental Virology, Department of Biology, University of Pisa, Via S. Zeno 35/39, Pisa 56127, Italy.
Scuola Normale Superiore, Piazza dei Cavalieri 7, Pisa 56126, Italy.
Int J Environ Res Public Health. 2016 Jul 20;13(7):733. doi: 10.3390/ijerph13070733.
Quantitative Microbial Risk Assessment (QMRA) methodology, which has already been applied to drinking water and food safety, may also be applied to risk assessment and management at the workplace. The present study developed a preliminary QMRA model to assess microbial risk that is associated with inhaling bioaerosols that are contaminated with human adenovirus (HAdV). This model has been applied to air contamination data from different occupational settings, including wastewater systems, solid waste landfills, and toilets in healthcare settings and offices, with different exposure times. Virological monitoring showed the presence of HAdVs in all the evaluated settings, thus confirming that HAdV is widespread, but with different average concentrations of the virus. The QMRA results, based on these concentrations, showed that toilets had the highest probability of viral infection, followed by wastewater treatment plants and municipal solid waste landfills. Our QMRA approach in occupational settings is novel, and certain caveats should be considered. Nonetheless, we believe it is worthy of further discussions and investigations.
定量微生物风险评估（QMRA）方法已应用于饮用水和食品安全领域，也可应用于工作场所的风险评估与管理。本研究开发了一个初步的QMRA模型，以评估与吸入被人类腺病毒（HAdV）污染的生物气溶胶相关的微生物风险。该模型已应用于不同职业环境的空气污染数据，包括废水系统、固体垃圾填埋场以及医疗场所和办公室的卫生间，且暴露时间各不相同。病毒学监测表明，在所有评估环境中均存在HAdV，从而证实HAdV广泛存在，但病毒的平均浓度有所不同。基于这些浓度的QMRA结果表明，卫生间病毒感染的可能性最高，其次是污水处理厂和城市固体垃圾填埋场。我们在职业环境中的QMRA方法具有创新性，应考虑某些注意事项。尽管如此，我们认为它值得进一步讨论和研究。
