Department of Neurosurgery, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany.
TUM-Neuroimaging Center, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany.
Brain Imaging Behav. 2017 Aug;11(4):1192-1206. doi: 10.1007/s11682-016-9574-x.
Human language organization models and language time course patterns are still predominantly derived from meta-analyses of numerous single publications, which only investigated scattered cortical regions. Moreover, there is not much literature available on the exact impact of repetitive navigated transcranial magnetic stimulation (rTMS) onset times on object naming. We, therefore, used a virtual lesion-based approach by mapping various cortical areas with rTMS to investigate the time course of object naming, and to specifically provide data on the pattern of rTMS language mapping results depending on different stimulation onset times. Ten healthy, right-handed subjects were enrolled, and rTMS in combination with an object-naming task was performed with different stimulation onset times (0 ms, 100 ms, 200 ms, 300 ms, 400 ms, and 500 ms). Subsequent to language mapping, all naming errors detected were systematically classified with respect to previous literature. The majority of errors was elicited within the opercular inferior frontal gyrus (opIFG) and ventral precentral gyrus (vPrG), and the spatial distribution of naming errors changed according to the time point of naming disruption by varying onset times. For instance, immediate rTMS onset led to a widespread cortical distribution of no responses, whereas performance and hesitation errors increased with higher stimulation onset times.
人类语言组织模型和语言时间进程模式仍然主要源自对大量单一出版物的荟萃分析，这些分析仅调查了分散的皮质区域。此外，关于重复经颅磁刺激 (rTMS) 起始时间对物体命名的确切影响的文献并不多。因此，我们使用了基于虚拟损伤的方法，通过 rTMS 对各种皮质区域进行映射，以研究物体命名的时间进程，并特别提供有关不同刺激起始时间的 rTMS 语言映射结果模式的数据。招募了 10 名健康的右利手受试者，并使用不同的刺激起始时间 (0 ms、100 ms、200 ms、300 ms、400 ms 和 500 ms) 进行 rTMS 结合物体命名任务。语言映射后，根据先前的文献系统地对所有检测到的命名错误进行分类。大多数错误是在脑岛下回（opIFG）和前中央回腹侧（vPrG）内引起的，命名干扰的时间点不同，命名错误的空间分布也会发生变化。例如，即时 rTMS 起始导致广泛的无反应皮质分布，而随着刺激起始时间的增加，表现和犹豫错误增加。
