Verhoef Talitha I, Trend Verena, Kelly Barry, Robinson Nigel, Fox Paul, Morris Stephen
Department of Applied Health Research, University College London, Gower Street, London, WC1E 6BT, UK.
Camden Borough Council, London, UK.
BMC Public Health. 2016 Jul 22;16:616. doi: 10.1186/s12889-016-3300-x.
We evaluated the cost-effectiveness of the Give-it-a-Go programme, which offers free leisure centre memberships to physically inactive members of the public in a single London Borough receiving state benefits.
A decision analytic Markov model was developed to analyse lifetime costs and quality-adjusted life-years (QALYs) of 1025 people recruited to the intervention versus no intervention. In the intervention group, people were offered 4 months of free membership at a leisure centre. Physical activity levels were assessed at 0 and 4 months using the International Physical Activity Questionnaire (IPAQ). Higher levels of physical activity were assumed to decrease the risk of coronary heart disease, stroke and diabetes mellitus type II, as well as improve mental health. Costs were assessed from a National Health Service (NHS) perspective. Uncertainty was assessed using one-way and probabilistic sensitivity analyses.
One-hundred fifty nine participants (15.5 %) completed the programme by attending the leisure centre for 4 months. Compared with no intervention, Give it a Go increased costs by £67.25 and QALYs by 0.0033 (equivalent to 1.21 days in full health) per recruited person. The incremental costs per QALY gained were £20,347. The results were highly sensitive to the magnitude of mental health gain due to physical activity and the duration of the effect of the programme (1 year in the base case analysis). When the mental health gain was omitted from the analysis, the incremental cost per QALY gained increased to almost £1.5 million. In the probabilistic sensitivity analysis, the incremental costs per QALY gained were below £20,000 in 39 % of the 5000 simulations.
Give it a Go did not significantly increase life-expectancy, but had a positive influence on quality of life due to the mental health gain of physical activity. If the increase in physical activity caused by Give it a Go lasts for more than 1 year, the programme would be cost-effective given a willingness to pay for a QALY of £20,000.
我们评估了“试试看”计划的成本效益,该计划为伦敦一个行政区内领取国家福利的缺乏身体活动的公众提供免费健身中心会员资格。
建立了一个决策分析马尔可夫模型,以分析1025名招募参加干预组与未参加干预组的人员的终身成本和质量调整生命年(QALYs)。在干预组中,人们可获得4个月的健身中心免费会员资格。使用国际体力活动问卷(IPAQ)在0个月和4个月时评估体力活动水平。假定较高的体力活动水平可降低冠心病、中风和II型糖尿病的风险,并改善心理健康。成本从英国国家医疗服务体系(NHS)的角度进行评估。使用单因素和概率敏感性分析评估不确定性。
159名参与者(15.5%)通过在健身中心参加4个月的活动完成了该计划。与不进行干预相比,“试试看”计划使每位招募人员的成本增加了67.25英镑,QALYs增加了0.0033(相当于1.21个完全健康日)。每获得一个QALY的增量成本为20347英镑。结果对体力活动带来的心理健康改善程度以及该计划效果的持续时间(基础案例分析中为1年)高度敏感。当分析中忽略心理健康改善时,每获得一个QALY的增量成本增加到近150万英镑。在概率敏感性分析中,在5000次模拟中,39%的情况下每获得一个QALY的增量成本低于20000英镑。
“试试看”计划并未显著提高预期寿命,但由于体力活动带来的心理健康改善,对生活质量有积极影响。如果“试试看”计划引起的体力活动增加持续超过1年,鉴于愿意为一个QALY支付20000英镑,该计划将具有成本效益。