Hu G, Qiao Q, Silventoinen K, Eriksson J G, Jousilahti P, Lindström J, Valle T T, Nissinen A, Tuomilehto J
Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland.
Diabetologia. 2003 Mar;46(3):322-9. doi: 10.1007/s00125-003-1031-x. Epub 2003 Feb 6.
AIM/HYPOTHESIS: Leisure-time physical activity can reduce the risk of Type 2 diabetes, but the potential effect of different types of physical activity is still uncertain. This study is to examine the relationship of occupational, commuting and leisure-time physical activity with the incidence of Type 2 diabetes.
We prospectively followed 6898 Finnish men and 7392 women of 35 to 64 years of age without a history of stroke, coronary heart disease, or diabetes at baseline. Hazards ratios of incidence of Type 2 diabetes were estimated by levels of occupational, commuting, and leisure-time physical activity.
During a mean follow-up of 12 years, there were 373 incident cases of Type 2 diabetes. In both men and women combined, the hazards ratios of diabetes associated with light, moderate and active work were 1.00, 0.70 and 0.74 (p=0.020 for trend) after adjustment for confounding factors (age, study year, sex, systolic blood pressure, smoking, education, the two other types of physical activity and BMI). The multivariate-adjusted hazards ratios of diabetes with none, 1 to 29, and more than 30 min of walking or cycling to and from work were 1.00, 0.96, and 0.64 (p=0.048 for trend). The multivariate-adjusted hazards ratios of diabetes for low, moderate, high levels of leisure-time physical activity were 1.00, 0.67, and 0.61 (p=0.001 for trend); after additional adjustment for BMI, the hazards ratio was no longer significant.
CONCLUSIONS/INTERPRETATION: Moderate and high occupational, commuting or leisure-time physical activity independently and significantly reduces risk of Type 2 diabetes among the middle-aged general population.
目的/假设：休闲时间进行体育活动可降低2型糖尿病风险，但不同类型体育活动的潜在影响仍不明确。本研究旨在探讨职业、通勤及休闲时间体育活动与2型糖尿病发病率之间的关系。
我们对6898名35至64岁、基线时无中风、冠心病或糖尿病病史的芬兰男性及7392名女性进行了前瞻性随访。根据职业、通勤及休闲时间体育活动水平估算2型糖尿病发病率的风险比。
在平均12年的随访期内，共出现373例2型糖尿病发病病例。在综合考虑男性和女性的情况下，在对混杂因素（年龄、研究年份、性别、收缩压、吸烟、教育程度、其他两种体育活动类型及体重指数）进行调整后，与轻度、中度和积极工作相关的糖尿病风险比分别为1.00、0.70和0.74（趋势p=0.020）。上下班步行或骑自行车时间分别为无、1至29分钟和超过30分钟时，经多变量调整后的糖尿病风险比分别为1.00、0.96和0.64（趋势p=0.048）。低、中、高水平休闲时间体育活动对应的经多变量调整后的糖尿病风险比分别为1.00、0.67和0.61（趋势p=0.001）；在对体重指数进行额外调整后，风险比不再显著。
结论/解读：中度和高强度的职业、通勤或休闲时间体育活动可独立且显著降低中年普通人群患2型糖尿病的风险。
