Martin David H, Marrazzo Jeanne M
Department of Epidemiology, Tulane University School of Public Health Departments of Medicine and Microbiology, Louisiana State University Health Sciences Center, New Orleans.
Department of Medicine, University of Alabama at Birmingham.
J Infect Dis. 2016 Aug 15;214 Suppl 1(Suppl 1):S36-41. doi: 10.1093/infdis/jiw184.
This article summarizes the highlights of the expert technical consultation on bacterial vaginosis (BV), sponsored by the National Institute of Allergy and Infectious Disease and held in Washington, DC, on 8-9 April 2015. Many issues touched on in this article are discussed in much greater detail in the 6 preceding articles in this supplement to The Journal of Infectious Diseases There was a consensus among the meeting attendees concerning the most important research issues in the field: the pathogenesis of the syndrome, way to optimize treatment, and the relative roles of sexual transmission and endogenous infection in BV epidemiology. This article concludes with a listing of BV and genitourinary tract research priorities that were discussed and agreed on by attendees. The most important of these included better characterization of vaginal microbiome community state subtypes, application of advanced "-omic" technologies to improve understanding of BV pathogenesis, further investigation of the relationships between the male and female genitourinary tract microbiomes, and the development of new drugs for BV treatment.
本文总结了由美国国立过敏与传染病研究所主办、于2015年4月8 - 9日在华盛顿特区举行的细菌性阴道病（BV）专家技术咨询会的要点。本文中涉及的许多问题在《传染病杂志》增刊的前6篇文章中有更详细的讨论。与会者就该领域最重要的研究问题达成了共识：该综合征的发病机制、优化治疗的方法以及性传播和内源性感染在BV流行病学中的相对作用。本文最后列出了与会者讨论并商定的BV和泌尿生殖道研究重点。其中最重要的包括更好地描述阴道微生物群落状态亚型、应用先进的“组学”技术以增进对BV发病机制的理解、进一步研究男性和女性泌尿生殖道微生物群之间的关系以及开发用于治疗BV的新药。
