Zhang Ya, Zhang Xiaomei, Liu Dongsheng, Wang Honghao, Pan Suyue, Wang Dongmei, Chen Xiong
Department of Neurology, Nanfang Hospital, Guangzhou, Guangdong Province, China.
Department of Neurology, GuangDong Province Hospital of Traditional Chinese Medicine Zhuhai Branch, Zhuhai, Guangdong Province, China.
Neurol Sci. 2016 Nov;37(11):1823-1829. doi: 10.1007/s10072-016-2628-4. Epub 2016 Jul 23.
Multiple sclerosis (MS) and neuromyelitis optica (NMO) are inflammatory demyelinating diseases of the central nervous system. In this study, the important role of fibrinogen in demyelination diseases was investigated. Plasma prothrombin time (PT), activated partial thrombin time (APTT), thrombin time (TT), fibrinogen, were measured among 189 patients with MS/NMO and 80 non-inflammatory neurological disease subjects as a control group. The Expanded Disability Status Scale (EDSS) was used to measure neurological impairment and disability of MS/NMO group. Fibrinogen levels were elevated in NMO and MS groups comparing with control ones, which was statistically associated with the severity of disease. Our results may lead to a better understanding of the etiopathogenesis of MS/NMO and contribute to prospects for preventions and treatments.
多发性硬化症（MS）和视神经脊髓炎（NMO）是中枢神经系统的炎性脱髓鞘疾病。在本研究中，对纤维蛋白原在脱髓鞘疾病中的重要作用进行了调查。在189例MS/NMO患者和80例非炎性神经系统疾病受试者作为对照组中，检测了血浆凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）、纤维蛋白原。采用扩展残疾状态量表（EDSS）来评估MS/NMO组的神经功能损害和残疾情况。与对照组相比，NMO组和MS组的纤维蛋白原水平升高，且与疾病严重程度具有统计学相关性。我们的研究结果可能有助于更好地理解MS/NMO的发病机制，并为预防和治疗提供思路。
