Kovalic J J, Perez C A
Radiation Oncology Center, Mallinckrodt Institute of Radiology, St. Louis, MO 63110.
Int J Radiat Oncol Biol Phys. 1989 Jul;17(1):77-80. doi: 10.1016/0360-3016(89)90373-8.
Radiation therapy following excision for keloids has been shown to decrease the recurrence rate by about 50%. We followed 75 patients with 113 keloids for a mean time of 9.75 years. Seventy-four percent of the lesions involved the earlobe. Superficial X ray therapy was used in 89% of the cases. The most frequent dose schedule was 12 Gy in three fractions over 3 days. The overall control rate was 73%. There was no advantage to starting radiation within 1 day of surgery. Keloids greater than 2 cm in size, those that had previous therapy, and those occurring in men were found to indicate a high likelihood of recurrence. The mean time to recurrence was 12.8 months. There were no complications from this low dose treatment. Radiotherapy following excision is an effective and safe adjuvant treatment for keloids.
瘢痕疙瘩切除术后进行放射治疗已被证明可使复发率降低约50%。我们对75例患者的113个瘢痕疙瘩进行了平均9.75年的随访。74%的病变累及耳垂。89%的病例采用了浅层X线治疗。最常用的剂量方案是在3天内分3次给予12 Gy。总体控制率为73%。在手术后1天内开始放疗没有优势。发现尺寸大于2 cm的瘢痕疙瘩、曾接受过治疗的瘢痕疙瘩以及男性患者的瘢痕疙瘩复发可能性较高。复发的平均时间为12.8个月。这种低剂量治疗没有并发症。切除术后放疗是一种治疗瘢痕疙瘩的有效且安全的辅助治疗方法。
