Wilberger Adam C, Prayson Richard A
From the Department of Pathology, University of Colorado School of Medicine, Aurora.
Department of Pathology, Cleveland Clinic, Cleveland, OH.
Am J Clin Pathol. 2016 Aug;146(2):156-62. doi: 10.1093/ajcp/aqw058. Epub 2016 Jul 24.
Intracranial plasma cell neoplasms (PCNs) arising from the skull, dura, or brain parenchyma are rare tumors and there is only a limited experience in the literature with these lesions.
We performed a retrospective clinicopathologic study of fourteen cases of intracranial PCN at our institution encountered over a 26-year-period.
The fourteen patients ranged in age from 30-74 years (median 66 years) and included seven males. For eight patients, their intracranial lesions were the initial presentation of multiple myeloma (MM). Three patients had prior history of MM; their intracranial tumors showed blastic plasma cell morphology, and all three died secondary to MM. The remaining three patients did not or have not developed MM.
PCNs rarely arise in the intracranial compartment. Intracranial PCN may be the initial presentation of MM. Anecdotally, blastic morphology appears to manifest more aggressive behavior.
起源于颅骨、硬脑膜或脑实质的颅内浆细胞瘤（PCNs）是罕见肿瘤，文献中关于这些病变的经验有限。
我们对本机构在26年期间遇到的14例颅内PCN进行了回顾性临床病理研究。
14例患者年龄在30 - 74岁之间（中位年龄66岁），其中男性7例。8例患者的颅内病变是多发性骨髓瘤（MM）的首发表现。3例患者有MM病史；他们的颅内肿瘤表现为原始浆细胞形态，且3例均死于MM。其余3例患者未发生或尚未发生MM。
PCNs很少发生于颅内。颅内PCN可能是MM的首发表现。据传闻，原始形态似乎表现出更具侵袭性的行为。
