一种用于阿尔茨海默病的血液筛查测试。
A blood screening test for Alzheimer's disease.
作者信息
O'Bryant Sid E, Edwards Melissa, Johnson Leigh, Hall James, Villarreal Alcibiades E, Britton Gabrielle B, Quiceno Mary, Cullum C Munro, Graff-Radford Neill R
机构信息
Institute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, TX, USA.
Department of Psychology, University of North Texas, Denton, TX, USA.
出版信息
Alzheimers Dement (Amst). 2016 Jun 25;3:83-90. doi: 10.1016/j.dadm.2016.06.004. eCollection 2016.
INTRODUCTION
This study combined data across four independent cohorts to examine the positive and negative predictive values of an Alzheimer's disease (AD) blood test if implemented in primary care.
METHODS
Blood samples from 1329 subjects from multiple independent, multiethnic, community-based, and clinic-based cohorts were analyzed. A "locked-down" referent group of 1128 samples was generated with 201 samples randomly selected for validation purposes. Random forest analyses were used to create the AD blood screen. Positive (PPV) and negative (NPV) predictive values were calculated.
RESULTS
In detecting AD, PPV was 0.81, and NPV was 0.95 while using the full AD blood test. When detecting mild cognitive impairment, PPV and NPV were 0.74 and 0.93, respectively. Preliminary analyses were conducted to detect any "neurodegenerative disease". The full 21-protein AD blood test yielded a PPV of 0.85 and NPV of 0.94.
DISCUSSION
The present study creates the first-ever multiethnic referent sample that spans community-based and clinic-based populations for implementation of an AD blood screen.
引言
本研究整合了来自四个独立队列的数据，以检验阿尔茨海默病（AD）血液检测若应用于初级保健中的阳性和阴性预测值。
方法
对来自多个独立、多民族、基于社区和基于诊所的队列的1329名受试者的血液样本进行了分析。生成了一个由1128个样本组成的“锁定”参照组，并随机选择201个样本用于验证目的。使用随机森林分析来创建AD血液筛查。计算了阳性（PPV）和阴性（NPV）预测值。
结果
在检测AD时，使用完整的AD血液检测，PPV为0.81，NPV为0.95。在检测轻度认知障碍时，PPV和NPV分别为0.74和0.93。进行了初步分析以检测任何“神经退行性疾病”。完整的21种蛋白质AD血液检测产生的PPV为0.85，NPV为0.94。
讨论
本研究创建了首个跨社区和诊所人群的多民族参照样本，用于实施AD血液筛查。
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