利用脑磁图记录分析弱外部经颅磁刺激对阿尔茨海默病患者大脑主要优势频率的影响。

Analyzing the Effect of Weak External Transcranial Magnetic Stimulation on the Primary Dominant Frequencies of Alzheimer Patients Brain by Using MEG Recordings.

作者信息

Anninos Photios, Adamopoulos Adam, Anninou Nikolia, Tsagas Nikolaos

机构信息

Laboratory of Medical Physics, Department of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.

Private Sector Veterinarian, 68100 Alexandroupolis, Greece.

出版信息

Medicina (Kaunas). 2021 Oct 26;57(11):1164. doi: 10.3390/medicina57111164.

DOI:10.3390/medicina57111164

PMID:34833381

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8622009/

Abstract

Alternative, non-invasive, and non-pharmaceutical options are gaining place in the battle of Alzheimer's Disease treatment control. Lately, the magnetic stimulation of the brain is the most prevalent technique with encouraging results. The aim of this study is to establish any possible change on the Primary Dominant Frequencies (PDF) (range 2-7 Hz) of the affected brain regions in Alzheimer Disease (AD) patients after applying extremely weak Transcranial Magnetic Stimulation. : For this purpose, all AD patients were scanned with the use of MagnetoEncephaloGraphy (MEG) recordings through a whole-head 122-channel MEG system. Our results exerted statistically significant PDF changes due to weak TMS accompanied by rabid attenuation of clinical symptoms. Thus, this is the first time that a positive therapeutic effect is being demonstrated even at pico-Tesla range magnetic fields in a small clinical group of studies for AD.

摘要

在阿尔茨海默病治疗控制的斗争中，替代性、非侵入性和非药物性选择正逐渐占据一席之地。最近，脑磁刺激是最流行的技术，且取得了令人鼓舞的结果。本研究的目的是确定在对阿尔茨海默病（AD）患者应用极弱经颅磁刺激后，受影响脑区的初级主导频率（PDF）（范围为2 - 7赫兹）是否发生任何可能的变化。为此，所有AD患者均通过全头122通道脑磁图（MEG）系统进行MEG记录扫描。我们的结果显示，由于弱经颅磁刺激导致PDF发生了具有统计学意义的变化，同时临床症状迅速减轻。因此，这是首次在针对AD的小型临床研究组中，即使在皮特斯拉范围的磁场中也证明了积极的治疗效果。