GCTA-GREML accounts for linkage disequilibrium when estimating genetic variance from genome-wide SNPs.
作者信息
Yang Jian, Lee S Hong, Wray Naomi R, Goddard Michael E, Visscher Peter M
机构信息
Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia; The University of Queensland Diamantina Institute, The Translation Research Institute, Brisbane, QLD 4102, Australia;
School of Environmental and Rural Science, University of New England, Armidale, NSW 2351, Australia;
出版信息
Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4579-80. doi: 10.1073/pnas.1602743113. Epub 2016 Jul 25.
Abstract
摘要
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GCTA-GREML accounts for linkage disequilibrium when estimating genetic variance from genome-wide SNPs.当从全基因组单核苷酸多态性（SNP）估计遗传方差时，GCTA-GREML考虑了连锁不平衡。
Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4579-80. doi: 10.1073/pnas.1602743113. Epub 2016 Jul 25.
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本文引用的文献
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Limitations of GCTA as a solution to the missing heritability problem.全基因组复杂性状分析（GCTA）作为解决“遗传性缺失”问题方法的局限性。
Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):E61-70. doi: 10.1073/pnas.1520109113. Epub 2015 Dec 22.
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Statistical power to detect genetic (co)variance of complex traits using SNP data in unrelated samples.利用无关样本中的单核苷酸多态性（SNP）数据检测复杂性状的遗传（共）方差的统计功效。
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Genome partitioning of genetic variation for complex traits using common SNPs.利用常见 SNP 对复杂性状的遗传变异进行基因组分区。
Nat Genet. 2011 Jun;43(6):519-25. doi: 10.1038/ng.823. Epub 2011 May 8.
4
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Am J Hum Genet. 2011 Jan 7;88(1):76-82. doi: 10.1016/j.ajhg.2010.11.011. Epub 2010 Dec 17.
5
Common SNPs explain a large proportion of the heritability for human height.常见的单核苷酸多态性解释了人类身高遗传的很大一部分。
Nat Genet. 2010 Jul;42(7):565-9. doi: 10.1038/ng.608. Epub 2010 Jun 20.
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