Lv S J, Lai D P, Wei X, Yan Q, Xia J M
Department of Emergency, Hangzhou Normal University Affiliated Hospital, Wenzhou Road 126, Hangzhou, 310015, Zhejiang, People's Republic of China.
Eur J Trauma Emerg Surg. 2017 Oct;43(5):711-715. doi: 10.1007/s00068-016-0713-2. Epub 2016 Jul 25.
The purpose of this study is to investigate the effect of Shenfu injection (SFI) on the tumor necrosis factor-α (TNF-α) and the interleukin (IL-6, IL-8, IL-10) of elderly patients who suffered from severe pneumonia.
From June 2012 to September 2014, we performed in our department 89 cases of elderly patients with severe pneumonia. These patients were randomly divided into two groups: the treatment group (45 cases) and the control group (44 cases). The control group was given the treatment of anti-infection, reducing sputum, and support therapy, while the treatment group was fed by SFI intravenously based on the control group. The TNF-α and the interleukin were detected by enzyme-linked immunosorbent assay (ELISA). Meanwhile, the changes in the inflammatory response indicators, the blood gas analysis, and the parameters of vital signs were measured and compared before and after therapy.
Prior to treatment, there is no significant difference between the treatment group and the control group (p > 0.05); after the treatment for 7 days, the levels of TNF-α, IL-6, and IL-8 were significantly decreased, while the level of IL-10 was obviously increased. The APACHE II score was significantly decreased in comparison to that before the treatment (p < 0.05), and the time of mechanical ventilation, the duration of time in ICU, and the application time of vasoactive drugs were notably shortened.
The application of Shenfu injection exhibited a positive and effective effect on removing the inflammation media during the treatment of elderly severe pneumonia.
本研究旨在探讨参附注射液（SFI）对老年重症肺炎患者肿瘤坏死因子-α（TNF-α）及白细胞介素（IL-6、IL-8、IL-10）的影响。
2012年6月至2014年9月，我科收治89例老年重症肺炎患者。这些患者随机分为两组：治疗组（45例）和对照组（44例）。对照组给予抗感染、化痰及支持治疗，治疗组在对照组基础上静脉滴注参附注射液。采用酶联免疫吸附测定（ELISA）法检测TNF-α及白细胞介素。同时，测定并比较治疗前后炎症反应指标、血气分析及生命体征参数的变化。
治疗前，治疗组与对照组无显著差异（p>0.05）；治疗7天后，TNF-α、IL-6及IL-8水平显著降低，而IL-10水平明显升高。急性生理与慢性健康状况评分系统（APACHE II）评分较治疗前显著降低（p<0.05），机械通气时间、入住重症监护病房（ICU）时间及血管活性药物应用时间明显缩短。
参附注射液在老年重症肺炎治疗中对清除炎症介质具有积极有效的作用。
