Jang Se Young, Park Soo Young, Lee Hye Won, Choi Yeon-Kyung, Park Keun-Gyu, Yoon Ghil Suk, Tak Won Young, Kweon Young Oh, Hur Keun, Lee Won Kee
Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.
Department of Pathology, Kyungpook National University Hospital, Daegu, Korea.
Gut Liver. 2016 Nov 15;10(6):948-954. doi: 10.5009/gnl15481.
BACKGROUND/AIMS: Periostin is an extracellular matrix protein and is known to be related to the metastatic potential and prognosis of cancer. However, few studies have investigated the expression level of periostin and its association with prognoses in hepatocellular carcinoma. Therefore, we analyzed periostin overexpression in hepatocellular carcinoma and its implication for prognoses.
We evaluated 149 patients who underwent surgical resection between 2006 and 2010. Tissue microarrays were constructed from hepatocellular carcinoma tissue and adjacent nontumor tissue, and immunohistochemistry was performed.
A high periostin level was observed more frequently in cases of multiple tumors (odds ratio [OR], 2.826; 95% confidence interval [CI], 1.224 to 6.527; p=0.013), positive microvascular invasion (OR, 2.974; 95% CI, 1.431 to 6.181; p=0.003), and advanced stage disease (OR, 3.032; 95% CI, 1.424 to 6.452; p=0.003). Patients with high periostin expression had significantly (p=0.002) lower overall survival rates than those with low periostin expression (90.3%, 66.1%, and 56.2% vs 97.7%, 85.1%, and 77.5% at 1, 3, and 5 years).
We found that a combination of periostin overexpression and microvascular invasion in hepatocellular carcinoma was correlated with a poor prognosis and can be a good prognostic marker for hepatocellular carcinoma.
背景/目的：骨膜蛋白是一种细胞外基质蛋白，已知与癌症的转移潜能和预后相关。然而，很少有研究调查骨膜蛋白在肝细胞癌中的表达水平及其与预后的关系。因此，我们分析了肝细胞癌中骨膜蛋白的过表达及其对预后的影响。
我们评估了2006年至2010年间接受手术切除的149例患者。从肝细胞癌组织和相邻的非肿瘤组织构建组织微阵列，并进行免疫组织化学检测。
在多肿瘤病例（优势比[OR]，2.826；95%置信区间[CI]，1.224至6.527；p = 0.013）、微血管侵犯阳性（OR，2.974；95%CI，1.431至6.181；p = 0.003）和晚期疾病（OR，3.032；95%CI，1.424至6.452；p = 0.003）中，骨膜蛋白高水平的观察更为频繁。骨膜蛋白高表达的患者总生存率显著低于骨膜蛋白低表达的患者（1年、3年和5年时分别为90.3%、66.1%和56.2%，而低表达患者分别为97.7%、85.1%和77.5%，p = 0.002）。
我们发现肝细胞癌中骨膜蛋白过表达与微血管侵犯相结合与预后不良相关，并且可以成为肝细胞癌的一个良好预后标志物。
