School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China.
National Engineering Research Center for the Pharmaceutics of Traditional Chinese Medicines, China.
Biomed Pharmacother. 2016 Oct;83:641-647. doi: 10.1016/j.biopha.2016.07.022. Epub 2016 Jul 25.
Platycladus orientalis (L.) Franco is traditionally known to potentiate hair growth promotion. However, there has been no report on its main active ingredient responsible for the hair growth activity. In the current work, cedrol as a major constituent from P. orientalis was evaluated for its potential on hair growth in vivo. Different concentrations of cedrol (10, 20 and 30mg/mL) were applied topically over the shaved skin of C57BL/6 mice and monitored for 21days. Results indicated that cedrol significantly promoted hair growth in a dose-dependent manner, particularly for the female mice. Both male and female mice groups treated with 30mg/mL cedrol required shorter time than the blank control and 2% minoxidil groups at different growth stages. Compared with the blank control (8.87mm) and 2% minoxidil (9.94mm) groups at 21days, the hair length of female mice treated with 30mg/mL cedrol showed a remarkable increase with the value of 11.07mm. Hair in male and female mice groups treated with 30mg/mL cedrol was heavier than the 2% minoxidil (38.2 and 35.9mg, respectively) groups with the weight of 42.6 and 45.2mg, respectively. Further observation of the hair follicle demonstrated that cedrol exerted a remarkable effect on the hair follicle length. These findings suggested that cedrol may be the main active ingredient of P. orientalis and have the potential of becoming a new hair growth promoter.
侧柏（Platycladus orientalis（L.）Franco）传统上被认为具有促进头发生长的作用。然而，目前还没有关于其促进头发生长活性的主要活性成分的报道。在目前的工作中，评估了柏科植物中的一种主要成分雪松醇（cedrol）在体内促进头发生长的潜力。将不同浓度的雪松醇（10、20 和 30mg/mL）局部应用于 C57BL/6 小鼠剃毛的皮肤上，并监测 21 天。结果表明，雪松醇以剂量依赖性方式显著促进头发生长，特别是对雌性小鼠。用 30mg/mL 雪松醇处理的雄性和雌性小鼠组在不同生长阶段所需的时间均短于空白对照组和 2%米诺地尔组。与空白对照组（8.87mm）和 2%米诺地尔组（9.94mm）相比，用 30mg/mL 雪松醇处理的雌性小鼠的毛发生长在 21 天时显著增加，数值为 11.07mm。用 30mg/mL 雪松醇处理的雄性和雌性小鼠的毛发重量均重于 2%米诺地尔组（分别为 38.2 和 35.9mg），分别为 42.6 和 45.2mg。进一步观察毛囊发现，雪松醇对毛囊长度有显著影响。这些发现表明，雪松醇可能是柏科植物的主要活性成分，具有成为新的毛发生长促进剂的潜力。
