miR-145-5p的下调与胃癌的不良预后相关。

Downregulation of miR-145-5p correlates with poor prognosis in gastric cancer.

作者信息

Zhang Y, Wen X, Hu X-L, Cheng L-Z, Yu J-Y, Wei Z-B

机构信息

Department of Oncology, Heping Hospital, Changzhi Medical College, Changzhi, Shanxi, P.R. China.

出版信息

Eur Rev Med Pharmacol Sci. 2016 Jul;20(14):3026-30.

PMID:27460730

Abstract

OBJECTIVE

The aim of this study was to explore the clinical significance of miR-145-5p expression in gastric cancer (GC).

PATIENTS AND METHODS

Expression of miR-145-5p was evaluated by qRT- PCR in tumor and normal gastric tissues in 145 GC patients. The correlation between the miR-145-5p expression and clinicopathological parameters was investigated. Finally, the survival was assessed by the Kaplan-Meier method and proportional hazards model.

RESULTS

Expression levels of miR-145-5p in GC tissues were significantly lower than those in adjacent normal tissues (p < 0.001). MiR-145-5p expression was significantly associated with lymph node metastasis, metastasis stage, and distant metastasis (all p < 0.05). Furthermore, Patients with low miR-145-5p expression had poorer overall survival time than those with high miR-145-5p expression (p = 0.014). Moreover, univariate and multivariate Cox analysis showed that miR-145-5p was an independent prognostic indicator for OS (p = 0.011).

CONCLUSIONS

MiR-145-5p is down-expressed in GC, and can be used as a marker of poor prognosis in GC patients.

摘要

目的

本研究旨在探讨miR-145-5p在胃癌（GC）中的表达的临床意义。

患者与方法

采用qRT-PCR检测145例GC患者肿瘤组织和正常胃组织中miR-145-5p的表达。研究miR-145-5p表达与临床病理参数之间的相关性。最后，采用Kaplan-Meier法和比例风险模型评估生存率。

结果

GC组织中miR-145-5p的表达水平显著低于相邻正常组织（p < 0.001）。miR-145-5p表达与淋巴结转移、转移分期和远处转移显著相关（均p < 0.05）。此外，miR-145-5p低表达患者的总生存时间比miR-145-5p高表达患者更差（p = 0.014）。而且，单因素和多因素Cox分析表明，miR-145-5p是OS的独立预后指标（p = 0.011）。