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A组轮状病毒肠胃炎:疫苗接种后时代、基因型与人畜共患病传播

Group A rotavirus gastroenteritis: post-vaccine era, genotypes and zoonotic transmission.

作者信息

Luchs Adriana, Timenetsky Maria do Carmo Sampaio Tavares

机构信息

Instituto Adolfo Lutz, São Paulo, SP, Brazil.

出版信息

Einstein (Sao Paulo). 2016 Apr-Jun;14(2):278-87. doi: 10.1590/S1679-45082016RB3582.

DOI:10.1590/S1679-45082016RB3582
PMID:27462899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4943361/
Abstract

ABSTRACTThis article provides a review of immunity, diagnosis, and clinical aspects of rotavirus disease. It also informs about the changes in epidemiology of diarrheal disease and genetic diversity of circulating group A rotavirus strains following the introduction of vaccines. Group A rotavirus is the major pathogen causing gastroenteritis in animals. Its segmented RNA genome can lead to the emergence of new or unusual strains in human populations via interspecies transmission and/or reassortment events.RESUMOEste artigo fornece uma revisão sobre imunidade, diagnóstico e aspectos clínicos da doença causada por rotavírus. Também aponta as principais mudanças no perfil epidemiológico da doença diarreica e na diversidade genética das cepas circulantes de rotavírus do grupo A, após a introdução vacinal. O rotavírus do grupo A é o principal patógeno associado à gastroenterite em animais. Seu genoma RNA segmentado pode levar ao surgimento de cepas novas ou incomuns na população humana, por meio de transmissão entre espécies e eventos de rearranjo.

摘要

摘要 本文综述了轮状病毒疾病的免疫、诊断及临床方面。本文还介绍了疫苗引入后腹泻病流行病学的变化以及流行的A组轮状病毒株的基因多样性。A组轮状病毒是导致动物胃肠炎的主要病原体。其分段RNA基因组可通过种间传播和/或重配事件在人群中导致新的或不寻常的毒株出现。

摘要 本文对轮状病毒病的免疫、诊断和临床方面进行了综述。它还说明了疫苗引入后腹泻病的流行病学变化以及流行的A组轮状病毒株的基因多样性。A组轮状病毒是与动物胃肠炎相关的主要病原体。其分段RNA基因组可通过种间传播和重排事件导致人群中出现新的或不常见的毒株。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4afb/4943361/edd9492e64a0/1679-4508-eins-14-2-0278-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4afb/4943361/edd9492e64a0/1679-4508-eins-14-2-0278-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4afb/4943361/edd9492e64a0/1679-4508-eins-14-2-0278-gf01.jpg

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