a 1 Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Hungária krt. 21, H-1143 Budapest, Hungary.
b 2 Department of Veterinary Public Health, University of Bari, S.p. per Casamassima km 3, 70010 Valenzano, Bari, Italy.
Expert Rev Anti Infect Ther. 2015;13(11):1337-50. doi: 10.1586/14787210.2015.1089171. Epub 2015 Oct 1.
Group A rotavirus (Rotavirus A, RVA) is the main cause of acute dehydrating diarrhea in humans and numerous animal species. RVA shows vast diversity and a variety of human strains share genetic and antigenic features with animal origin RVA strains. This finding suggests that interspecies transmission is an important mechanism of rotavirus evolution and contributes to the diversity of human RVA strains. RVA is responsible for half a million deaths and several million hospitalizations worldwide. Globally, two rotavirus vaccines are available for routine use in infants. These vaccines show a great efficacy profile and induce protective immunity against various rotavirus strains. However, little is known about the long-term evolution and epidemiology of RVA strains under selective pressure related to vaccine use. Continuous strain surveillance in the post-vaccine licensure era is needed to help better understand mechanisms that may affect vaccine effectiveness.
A 组轮状病毒（Rotavirus A，RVA）是导致人类和众多动物物种急性脱水性腹泻的主要原因。RVA 表现出巨大的多样性，并且许多人类株与动物源 RVA 株具有遗传和抗原特征。这一发现表明种间传播是轮状病毒进化的重要机制，并有助于人类 RVA 株的多样性。RVA 导致全世界有 50 万人死亡和数百万人住院。在全球范围内，有两种轮状病毒疫苗可用于常规接种婴儿。这些疫苗具有很好的疗效，并对各种轮状病毒株产生保护免疫。然而，对于疫苗使用相关的选择性压力下 RVA 株的长期进化和流行病学，我们知之甚少。在疫苗获得许可后时代，需要持续进行菌株监测，以帮助更好地了解可能影响疫苗效果的机制。
