De Luca Francesco
Pediatr Endocrinol Rev. 2016 Jun;13(4):720-30.
Abstract Nuclear Factor kappa B (NF-κB) is a group of seven transcription factors. Upon activation by a variety of stimuli, NF-κB translocates to the nucleus and modulates the expression of target genes involved in cell growth, survival, and death. Previous evidence indicates that NF-κB regulates bone growth and development. We have shown that the NF-κB p65 is expressed in the growth plate and facilitates longitudinal bone growth by inducing chondrocyte proliferation and differentiation and by preventing apoptosis. Furthermore, we have demonstrated in rodents that NF-κB expressed in growth plate chondrocytes mediates the promoting effects of GH and IGF-1 on longitudinal bone growth and growth plate chondrogenesis. Lastly, functional studies carried out in two children with growth failure and GH insensitivity, and affected by two different mutations impairing NF-κB activation, indicate that NF-κB also mediates the growth-promoting effects of GH in humans.
摘要 核因子κB（NF-κB）是一组七种转录因子。在受到多种刺激激活后，NF-κB易位至细胞核并调节参与细胞生长、存活和死亡的靶基因的表达。先前的证据表明NF-κB调节骨骼生长和发育。我们已经表明，NF-κB p65在生长板中表达，并通过诱导软骨细胞增殖和分化以及防止细胞凋亡促进纵向骨生长。此外，我们在啮齿动物中证明，生长板软骨细胞中表达的NF-κB介导生长激素（GH）和胰岛素样生长因子-1（IGF-1）对纵向骨生长和生长板软骨形成的促进作用。最后，在两名生长发育迟缓且对GH不敏感、受两种不同的损害NF-κB激活的突变影响的儿童中进行的功能研究表明，NF-κB也介导GH在人类中的促生长作用。
