神经梅毒——一种极易误诊的疾病：病例报告
Neurosyphilis as a great imitator: a case report.
作者信息
Sabre Liis, Braschinsky Mark, Taba Pille
机构信息
Department of Neurology, Neurology Clinic, Tartu University Hospital, 8 L. Puusepa Street, 51014, Tartu, Estonia.
Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia.
出版信息
BMC Res Notes. 2016 Jul 28;9:372. doi: 10.1186/s13104-016-2176-2.
BACKGROUND
Neurosyphilis is defined as any involvement of the central nervous system by the bacterium Treponema pallidum. Movement disorders as manifestations of syphilis have been reported quite rarely.
CASE PRESENTATION
We report a case of a 42-year-old Russian man living in Estonia with rapidly progressive dementia and movement disorders manifesting as myoclonus, cerebellar ataxia and parkinsonism. The mini mental state examination score was 12/30. After excluding different neurodegenerative causes, further diagnostic testing was consistent with neurosyphilis. Treatment with penicillin was started and 6 months later his mini mental state examination score was 25/30 and he had no myoclonus, parkinsonism or cerebellar dysfunction.
CONCLUSION
Since syphilis is easily diagnosed and treatable, it should be considered and tested in patients with cognitive impairment and movement disorders.
背景
神经梅毒被定义为梅毒螺旋体对中枢神经系统的任何累及。梅毒表现为运动障碍的情况鲜有报道。
病例报告
我们报告一例居住在爱沙尼亚的42岁俄罗斯男子，患有快速进展性痴呆和运动障碍，表现为肌阵挛、小脑共济失调和帕金森综合征。简易精神状态检查表评分12/30。排除不同的神经退行性病因后，进一步的诊断检测结果与神经梅毒相符。开始使用青霉素治疗，6个月后其简易精神状态检查表评分25/30，且无肌阵挛、帕金森综合征或小脑功能障碍。
结论
由于梅毒易于诊断且可治疗，对于有认知障碍和运动障碍的患者应考虑并进行相关检测。
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