Jakeman Steven A, Henry Courtney N, Martin Berdine R, McCabe George P, McCabe Linda D, Jackson George S, Peacock Munro, Weaver Connie M
Departments of Food Science.
Statistics.
Am J Clin Nutr. 2016 Sep;104(3):837-43. doi: 10.3945/ajcn.116.132761. Epub 2016 Jul 27.
Dietary soluble corn fiber (SCF) significantly improves calcium absorption in adolescents and the bone strength and architecture in rodent models.
In this study, we aimed to determine the skeletal benefits of SCF in postmenopausal women.
We used our novel technology of determining bone calcium retention by following the urinary appearance of (41)Ca, a rare long-lived radioisotope, from prelabeled bone to rapidly and sensitively evaluate the effectiveness of SCF in reducing bone loss. A randomized-order, crossover, double-blinded trial was performed in 14 healthy postmenopausal women to compare doses of 0, 10, and 20 g fiber from SCF/d for 50 d.
A dose-response effect was shown with 10 and 20 g fiber from SCF/d, whereby bone calcium retention was improved by 4.8% (P < 0.05) and 7% (P < 0.04), respectively. The bone turnover biomarkers N-terminal telopeptide and osteocalcin were not changed by the interventions; however, a significant increase in bone-specific alkaline phosphatase, which is a bone-formation marker, was detected between 0 and 20 g fiber from SCF/d (8%; P = 0.035).
Daily SCF consumption significantly increased bone calcium retention in postmenopausal women, which improved the bone calcium balance by an estimated 50 mg/d. This study was registered at clinicaltrials.gov as NCT02416947.
膳食中的可溶性玉米纤维（SCF）能显著提高青少年的钙吸收，并改善啮齿动物模型的骨强度和骨结构。
在本研究中，我们旨在确定SCF对绝经后女性骨骼的益处。
我们采用了一种新技术，即通过追踪预标记骨中罕见的长寿命放射性同位素（41）Ca在尿液中的出现情况来测定骨钙潴留，从而快速、灵敏地评估SCF在减少骨质流失方面的有效性。对14名健康绝经后女性进行了一项随机顺序、交叉、双盲试验，比较每天0、10和20克SCF纤维剂量，持续50天。
每天10克和20克SCF纤维呈现剂量反应效应，骨钙潴留分别提高了4.8%（P<0.05）和7%（P<0.04）。干预措施未改变骨转换生物标志物N端肽和骨钙素；然而，在每天0克和20克SCF纤维之间检测到骨特异性碱性磷酸酶（一种骨形成标志物）显著增加（8%；P = 0.035）。
每日食用SCF可显著增加绝经后女性的骨钙潴留，估计可使骨钙平衡每天改善50毫克。本研究已在clinicaltrials.gov上注册，注册号为NCT02416947。
