Okazaki Yukako, Chiji Hideyuki, Kato Norihisa
Faculty of Human Life Sciences, Fuji Women's University.
J Nutr Sci Vitaminol (Tokyo). 2016;62(3):206-12. doi: 10.3177/jnsv.62.206.
Lily bulb is traditionally consumed in East Asia and contains high amounts of glucomannan. This study investigated the effect of dietary lily bulb on dextran sulfate sodium (DSS)-induced colitis in rats fed a high-fat (HF) diet. Male Sprague-Dawley rats were fed a diet containing 30% beef tallow with or without 7% steamed lily bulb powder for 17 d. Experimental colitis was induced by replacing drinking water with DSS during the last 7 d. The disease activity index (DAI) was significantly lower in the lily bulb+DSS group than in the DSS group on day 17. The fecal abundance of Bifidobacterium was significantly reduced in the DSS group compared with that in the control group, but it was recovered by lily bulb intake. Cecal butyrate, fecal mucins, and alkaline phosphatase (ALP) activity were significantly higher in the DSS group than in the control group. Dietary lily bulb potentiated the increase in cecal butyrate, fecal mucins, and the ALP activity caused by DSS treatment. These results indicate that lily bulb attenuates DSS-induced colitis by modulating colonic microflora, organic acids, mucins, and ALP activity in HF diet-fed rats.
在东亚地区，人们传统上食用百合鳞茎，其含有大量的葡甘露聚糖。本研究调查了在高脂（HF）饮食喂养的大鼠中，日粮添加百合鳞茎对葡聚糖硫酸钠（DSS）诱导的结肠炎的影响。雄性Sprague-Dawley大鼠喂养含30%牛脂的日粮，添加或不添加7%蒸制百合鳞茎粉，持续17天。在最后7天，用DSS替代饮用水诱导实验性结肠炎。在第17天，百合鳞茎+DSS组的疾病活动指数（DAI）显著低于DSS组。与对照组相比，DSS组粪便中双歧杆菌的丰度显著降低，但通过摄入百合鳞茎得以恢复。DSS组盲肠丁酸、粪便粘蛋白和碱性磷酸酶（ALP）活性显著高于对照组。日粮添加百合鳞茎增强了DSS处理引起的盲肠丁酸、粪便粘蛋白和ALP活性的增加。这些结果表明，在高脂饮食喂养的大鼠中，百合鳞茎通过调节结肠微生物群、有机酸、粘蛋白和ALP活性减轻DSS诱导的结肠炎。
