Leese Henry J, Guerif Fabrice, Allgar Victoria, Brison Daniel R, Lundin Kersti, Sturmey Roger G
Centre for Cardiovascular Metabolic Research, Hull York Medical School, University of Hull, Hull, United Kingdom.
Medecine et Biologie de la Reproduction, Université de Tours, Tours, France.
Mol Reprod Dev. 2016 Sep;83(9):748-754. doi: 10.1002/mrd.22684.
The quiet embryo hypothesis postulates that early embryo viability is associated with a relatively low metabolism (Leese, 2002 BioEssays 24: 845-849). This proposal is re-visited here using retrospective and prospective data on the metabolic activity and kinetics of preimplantation development alongside the concept that an optimal range of such indices and of energetic efficiency influences embryogenesis. It is concluded that these considerations may be rationalized by proposing the existence of a "Goldilocks zone," or as it is known in Sweden, of lagom-meaning "just the right amount"-within which embryos with maximum developmental potential can be categorized. Mol. Reprod. Dev. 83: 748-754, 2016 © 2016 Wiley Periodicals, Inc.
安静胚胎假说假定早期胚胎的活力与相对较低的代谢有关（Leese，2002年，《生物论文》24：845 - 849）。本文利用关于植入前发育的代谢活性和动力学的回顾性和前瞻性数据，以及这些指标的最佳范围和能量效率影响胚胎发生的概念，重新审视了这一观点。得出的结论是，通过提出存在一个“金发姑娘区”（在瑞典被称为lagom，意为“刚刚好的量”），在这个范围内具有最大发育潜力的胚胎可以被分类，这些考虑因素可能是合理的。《分子生殖与发育》83：748 - 754，2016年 © 2016威利期刊公司
