Käsmann Lukas, Janssen Stefan, Rades Dirk
Department of Radiation Oncology, University of Lübeck, Lübeck, Germany
Department of Radiation Oncology, University of Lübeck, Lübeck, Germany Practice of Radiotherapy and Radiation Oncology, Hannover, Germany.
Anticancer Res. 2016 Aug;36(8):4177-80.
Elderly patients require special consideration in oncology treatment. Small-cell lung cancer (SCLC) is a highly aggressive tumour with dismal prognosis. The present study focused on prognostic factors in elderly patients irradiated for limited-disease SCLC.
In 36 patients aged ≥65 years, 11 factors were evaluated for the impact on survival, namely gender, Karnofsky performance score, body mass index, T-category, N-category, tobacco consumption, time from SCLC diagnosis to irradiation, smoking during irradiation, simultaneous chemotherapy, radiation dose and prophylactic cranial irradiation.
On multivariate analysis, Karnofsky performance score of >70 (p<0.001), N-category 0-2 (p≤0.001) and total radiation dose of >52 Gy (p=0.011) were significantly associated with better survival.
Significant predictors of survival in elderly patients irradiated for limited-disease SCLC were identified. A radiation dose of >52 Gy resulted in improved survival when compared to lower doses.
老年患者在肿瘤治疗中需要特殊考虑。小细胞肺癌（SCLC）是一种侵袭性很强的肿瘤，预后很差。本研究聚焦于接受局限性疾病SCLC放疗的老年患者的预后因素。
对36例年龄≥65岁的患者，评估了11个因素对生存的影响，即性别、卡氏功能状态评分、体重指数、T分期、N分期、吸烟量、从SCLC诊断到放疗的时间、放疗期间吸烟、同步化疗、放射剂量和预防性颅脑照射。
多因素分析显示，卡氏功能状态评分>70（p<0.001）、N分期0-2（p≤0.001）和总放射剂量>52 Gy（p=0.011）与更好的生存显著相关。
确定了接受局限性疾病SCLC放疗的老年患者生存的显著预测因素。与较低剂量相比，放射剂量>52 Gy可提高生存率。
