Fikatas Panagiotis, Klein Fritz, Andreou Andreas, Schmuck Rosa Bianca, Pratschke Johann, Bahra Marcus
Department of General, Visceral and Transplantation Surgery, Charité - Universitaetsmedizin Berlin, Berlin, Germany
Department of General, Visceral and Transplantation Surgery, Charité - Universitaetsmedizin Berlin, Berlin, Germany.
Anticancer Res. 2016 Aug;36(8):4273-8.
The role of radical pancreatic surgery for metastatic lesions of renal cell carcinoma (RCC) remains unclear.
In this analysis, 19 patients underwent pancreatic resections for metastases of RCC between 2000 and 2014.
Pancreatic metastases were diagnosed 10.2±27.1 years after primary diagnosis of RCC. Surgical approaches included pylorus preserving pancreatoduodenectomy (PPPD) (n=10, 55.6%), followed by distal pancreatectomy (n=5, 27.8%) and total pancreatectomy (n=4, 22.2%). The survival after 1, 3 and 5 years was 88.9%, 80% and 71.4%, respectively. Patients after PPPD procedure had a significant worse survival (p=0.030). RCC stage VI tumors seem to be associated with decreased short- and long-term survival rates (p=0.03). Additional metastatic lesions in the further postoperative course had no impact on outcome.
The results of our analysis demonstrate promising long-term results with regard to disease-free and overall survival after surgical therapy for pancreatic metastases of renal cell carcinoma.
根治性胰腺手术在肾细胞癌（RCC）转移灶治疗中的作用仍不明确。
本分析纳入了2000年至2014年间19例行胰腺切除术治疗RCC转移灶的患者。
胰腺转移灶在RCC初次诊断后10.2±27.1年被诊断。手术方式包括保留幽门的胰十二指肠切除术（PPPD）（n = 10，55.6%），其次是胰体尾切除术（n = 5，27.8%）和全胰切除术（n = 4，22.2%）。1年、3年和5年生存率分别为88.9%、80%和71.4%。接受PPPD手术的患者生存率显著较差（p = 0.030）。RCC VI期肿瘤似乎与短期和长期生存率降低相关（p = 0.03）。术后进一步病程中出现的其他转移灶对预后无影响。
我们的分析结果表明，肾细胞癌胰腺转移灶手术治疗后的无病生存期和总生存期有良好的长期结果。
