Mohr Audrey, Renaudineau Yves, Bagacean Cristina, Pers Jacques-Olivier, Jamin Christophe, Bordron Anne
INSERM ESPRI ERI29/EA2216 Laboratory of Immunotherapies and Pathologies of B Lymphocytes, Université de Brest, Labex IGO "Immunotherapy Graft, Oncology," Reseau Epigenetique et Reseau Canaux Ioniques du Cancéropole Grand Ouest , Brest, France.
INSERM ESPRI ERI29/EA2216 Laboratory of Immunotherapies and Pathologies of B Lymphocytes, Université de Brest, Labex IGO "Immunotherapy Graft, Oncology," Reseau Epigenetique et Reseau Canaux Ioniques du Cancéropole Grand Ouest, Brest, France; Laboratory of Immunology and Immunotherapy, CHRU Morvan, Brest, France.
Oncoimmunology. 2016 Mar 16;5(5):e1132977. doi: 10.1080/2162402X.2015.1132977. eCollection 2016 May.
Chronic lymphocytic leukemia (CLL) is characterized by an abnormal expansion of mature B cells in the bone marrow and their accumulation in blood and secondary lymphoid organs. Tumor CLL cells share expression of various surface molecules with many subsets of B cells and have several common characteristics with regulatory B cells (B regs). However, the identification of B regs and their role in CLL remain elusive. The aim of this review is to summarize recent works regarding the regulatory and phenotypic characteristic of B regs and their associated effects on the immune system. It is also meant to highlight their potential importance with regards to the immunotherapeutic response.
慢性淋巴细胞白血病（CLL）的特征是骨髓中成熟B细胞异常扩增，并在血液和二级淋巴器官中积聚。肿瘤性CLL细胞与许多B细胞亚群共享各种表面分子的表达，并与调节性B细胞（Bregs）具有几个共同特征。然而，Bregs的鉴定及其在CLL中的作用仍然难以捉摸。本综述的目的是总结关于Bregs的调节和表型特征及其对免疫系统相关影响的近期研究。它还旨在强调它们在免疫治疗反应方面的潜在重要性。
