Abdel-Sater Khaled A, Hassan Heba A
Department of Dental and Medical Sciences, Faculty of Dentistry, Mutah University, Al-Karak, Jordan.
Department of Clinical Pharmacology, Faculty of Medicine, Mutah University, Al-Karak, Jordan.
Front Neurosci. 2025 Jul 10;19:1594179. doi: 10.3389/fnins.2025.1594179. eCollection 2025.
Neurotransmitters are key signaling molecules in the brain-gut axis, may be involved in stress-induced ulcer damage.
This study aims to address the relationship between gut microbiota and the stress response is examined in this review, with a focus on how neurotransmitters moderate the impact of stress on mucosal integrity and gut health. Understanding these mechanisms may open new avenues for therapeutic interventions targeting the brain-gut axis.
A literature search was completed using PubMed, Web of Science, Cochrane, PsycINFO, Scopus and Embase databases for clinical and preclinical studies related to stress ulcer, gut microbiota and gut brain axis that published in English until November 2024.
The gut microbiota plays important role in preserving the health of the digestive system and influencing the body's stress response through various pathways, including the enteric and autonomic nervous systems. This results in the production of microbial metabolites such as bile acids, tryptophan, and short-chain fatty acids that enter the bloodstream and go to the brain. Microbial neurotransmitters change the brain's gastrointestinal axis.
The connection between stress ulcer, neurotransmitters, and the gut microbiota was outlined in this review.
神经递质是脑-肠轴中的关键信号分子，可能参与应激诱导的溃疡损伤。
本综述探讨肠道微生物群与应激反应之间的关系，重点关注神经递质如何调节应激对黏膜完整性和肠道健康的影响。了解这些机制可能为针对脑-肠轴的治疗干预开辟新途径。
使用PubMed、科学网、Cochrane、PsycINFO、Scopus和Embase数据库完成文献检索，以查找截至2024年11月发表的与应激性溃疡、肠道微生物群和肠脑轴相关的临床和临床前英文研究。
肠道微生物群在维持消化系统健康和通过各种途径（包括肠神经系统和自主神经系统）影响身体应激反应方面发挥着重要作用。这导致产生胆汁酸、色氨酸和短链脂肪酸等微生物代谢产物，这些产物进入血液并输送到大脑。微生物神经递质改变大脑的胃肠轴。
本综述概述了应激性溃疡、神经递质和肠道微生物群之间的联系。
