Foraker Randi E, Tumin Dmitry, Smith Sakima, Tobias Joseph D, Hayes Don
Division of Epidemiology, The Ohio State University College of Public Health, Columbus, Ohio; Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, Ohio; Center for Epidemiology of Organ Failure and Transplantation, Nationwide Children's Hospital, Columbus, Ohio.
Center for Epidemiology of Organ Failure and Transplantation, Nationwide Children's Hospital, Columbus, Ohio; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio; Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, Columbus, Ohio.
J Heart Lung Transplant. 2016 Dec;35(12):1480-1486. doi: 10.1016/j.healun.2016.06.012. Epub 2016 Jun 24.
Heart transplantation outcomes differ by health insurance status and geographic region of the United States. We hypothesized that heart transplantation survival would be affected by health insurance status within certain United Network for Organ Sharing (UNOS) regions.
We used data from the UNOS thoracic database to classify health insurance status into private or public (private/self-pay or Medicare/Medicaid) for all first-time heart transplant recipients between July 2006 and September 2013. We applied Cox proportional hazards regression to estimate hazard ratio (HR) and 95% confidence interval (CI) for the influences of health insurance status on 1-year and long-term survival in heart transplant recipients by UNOS region.
Mean survival time among 10,474 patients was 942 days ± 704. All key demographic and clinical variables varied significantly across UNOS regions. With respect to 1-year survival, patients in Region 2 had a higher hazard of mortality (HR, 1.49; 95% CI, 1.03, 2.15) if they had public vs private insurance. When we restricted the analysis to be conditional on 1-year survival, 2 contiguous regions, Region 10, including Indiana, Ohio, Michigan (HR, 2.30; 95% CI, 1.23, 4.28), and Region 11 (HR, 1.85; 95% CI, 1.15, 2.97), including the upper South, had poor survival associated with public vs private insurance.
The data we present invite targeted efforts by certain UNOS regions to improve the standard of care and/or eligibility thresholds for heart transplant recipients.
在美国,心脏移植的结果因健康保险状况和地理区域而异。我们假设,在器官共享联合网络(UNOS)的某些区域内,心脏移植的存活率会受到健康保险状况的影响。
我们使用UNOS胸科数据库的数据,将2006年7月至2013年9月期间所有首次接受心脏移植的受者的健康保险状况分为私人保险或公共保险(私人/自费或医疗保险/医疗补助)。我们应用Cox比例风险回归来估计健康保险状况对UNOS区域内心脏移植受者1年和长期生存影响的风险比(HR)和95%置信区间(CI)。
10474名患者的平均生存时间为942天±704天。所有关键的人口统计学和临床变量在UNOS各区域之间存在显著差异。关于1年生存率,如果接受公共保险而非私人保险,第2区域的患者死亡风险更高(HR,1.49;95%CI,1.03,2.15)。当我们将分析限制在以1年生存率为条件时,包括印第安纳州、俄亥俄州、密歇根州的第10区域(HR,2.30;95%CI,1.23,4.28)和包括上南部地区的第11区域(HR,1.85;95%CI,1.15,2.97)这两个相邻区域,公共保险与私人保险相比生存率较差。
我们提供的数据促使UNOS的某些区域做出有针对性的努力,以提高心脏移植受者的护理标准和/或资格门槛。