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[日本寻常型银屑病患者中补体成分与HLA抗原的相关基因变异]

[Genetic variants of the complement components and HLA-antigens associated in patients with psoriasis vulgaris in Japanese].

作者信息

Nakagawa H, Tokunaga K, Dewald G, Omoto K, Ishibashi Y, Matsuki K, Juji T

出版信息

Nihon Hifuka Gakkai Zasshi. 1989 Jan;99(1):77-81.

PMID:2746964
Abstract

Genetic polymorphisms of the serum complement components (C2, C4, C6, and C7) and HLA-antigens were studied in Japanese patients with psoriasis vulgaris. Among these complement components, positive associations with C4A4 and C4B2 were obtained. In addition to the previously reported haplotypes HLA-Cw6-B13 and Cw6-Bw57-DR7, the extended haplotype HLA-Cw11-Bw46-C4A4. 4B2-BFS-C2C-DRw8 may be a high risk haplotype in Japanese patients with psoriasis vulgaris.

摘要

对日本寻常型银屑病患者的血清补体成分（C2、C4、C6和C7）及人类白细胞抗原（HLA）进行了基因多态性研究。在这些补体成分中，发现与C4A4和C4B2呈正相关。除了先前报道的单倍型HLA - Cw6 - B13和Cw6 - Bw57 - DR7外，扩展单倍型HLA - Cw11 - Bw46 - C4A4. 4B2 - BFS - C2C - DRw8可能是日本寻常型银屑病患者的高危单倍型。

相似文献

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[Genetic variants of the complement components and HLA-antigens associated in patients with psoriasis vulgaris in Japanese].[日本寻常型银屑病患者中补体成分与HLA抗原的相关基因变异]
Nihon Hifuka Gakkai Zasshi. 1989 Jan;99(1):77-81.
2
Study of HLA class I, class II and complement genes (C2, C4A, C4B and BF) in Japanese psoriatics and analysis of a newly-found high-risk haplotype by pulsed field gel electrophoresis.
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Further study on HLA-A, B, C, D, DR and haplotype antigen frequencies in psoriasis vulgaris.寻常型银屑病中HLA - A、B、C、D、DR及单倍型抗原频率的进一步研究
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引用本文的文献

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Hla-a and hla-B alleles associated in psoriasis patients from mumbai, Western India.印度西部孟买银屑病患者中相关的Hla - a和hla - B等位基因。
Indian J Dermatol. 2011 Sep-Oct;56(5):497-500. doi: 10.4103/0019-5154.87128.
2
Correlation between HLA-A2-Bw46-DRw8 haplotype and increased levels of complement components (C4 and C4a) in patients with psoriatic arthritis.
Arch Dermatol Res. 1991;283(5):347-9. doi: 10.1007/BF00376626.