Mentoor Juliet L D, Lubisi Alison B, Gerdes Truuska, Human Stacey, Williams June H, Venter Marietjie
Zoonosis Research Unit, Department Medical Virology, University of Pretoria, Pretoria, South Africa.
Virology Molecular Epidemiology and Diagnostics Programme, Agricultural Research Council, Onderstepoort Veterinary Institute, Pretoria, South Africa.
Genome Announc. 2016 Jul 28;4(4):e00740-16. doi: 10.1128/genomeA.00740-16.
We report here the complete genome sequence of a lineage 2 West Nile virus (WNV) strain that resulted in fatal neurological disease in a horse in South Africa. Several recent reports exist of neurological disease associated with lineage 2 WNV in humans and horses in South Africa and Europe; however, there are a lack of sequencing data from recent fatal cases in Southern Africa, where these strains likely originate. A better understanding of the genetic composition of highly neuroinvasive lineage 2 strains may facilitate the identification of putative genetic factors associated with increased virulence.
我们在此报告一株2型西尼罗河病毒（WNV）的全基因组序列，该病毒株在南非一匹马身上引发了致命的神经疾病。最近有几份报告称，在南非和欧洲，人类和马匹中出现了与2型WNV相关的神经疾病；然而，在这些毒株可能起源的南部非洲，缺乏近期致命病例的测序数据。更好地了解具有高度神经侵袭性的2型毒株的基因组成，可能有助于识别与毒力增加相关的假定遗传因素。
