中国仓鼠卵巢细胞突变体中胆固醇生物合成和质膜流动性的调节缺陷。
Defective regulation of cholesterol biosynthesis and plasma membrane fluidity in a Chinese hamster ovary cell mutant.
作者信息
Sinensky M
出版信息
Proc Natl Acad Sci U S A. 1978 Mar;75(3):1247-9. doi: 10.1073/pnas.75.3.1247.
Abstract
A Chinese hamster ovary cell mutant resistant to killing by 25-hydroxycholesterol is shown to be defective in the regulation of cholesterol synthesis by exogenous cholesterol. When grown with various cholesterol supplements in delipidized serum, the mutant cell exhibits a variation in cholesterol content and plasma membrane fluidity that is not observed in the parental cell type.
摘要
一种对25-羟基胆固醇杀伤具有抗性的中国仓鼠卵巢细胞突变体，被证明在通过外源性胆固醇调节胆固醇合成方面存在缺陷。当在脱脂血清中添加各种胆固醇补充剂培养时，该突变体细胞的胆固醇含量和质膜流动性会发生变化，而在亲代细胞类型中未观察到这种变化。
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