Nozaki Daichi, Yokoi Atsushi, Kimura Takahiro, Hirashima Masaya, Orban de Xivry Jean-Jacques
Division of Physical and Health Education, Graduate School of Education, The University of Tokyo, Tokyo, Japan.
The Brain and Mind Institute, University of Western Ontario, London, Canada.
Elife. 2016 Jul 29;5:e15378. doi: 10.7554/eLife.15378.
We demonstrate that human motor memories can be artificially tagged and later retrieved by noninvasive transcranial direct current stimulation (tDCS). Participants learned to adapt reaching movements to two conflicting dynamical environments that were each associated with a different tDCS polarity (anodal or cathodal tDCS) on the sensorimotor cortex. That is, we sought to determine whether divergent background activity levels within the sensorimotor cortex (anodal: higher activity; cathodal: lower activity) give rise to distinct motor memories. After a training session, application of each tDCS polarity automatically resulted in the retrieval of the motor memory corresponding to that polarity. These results reveal that artificial modulation of neural activity in the sensorimotor cortex through tDCS can act as a context for the formation and recollection of motor memories.
我们证明，人类运动记忆可以通过非侵入性经颅直流电刺激（tDCS）进行人工标记并随后被提取。参与者学习将伸手动作适应两种相互冲突的动态环境，每种环境在感觉运动皮层上都与不同的tDCS极性（阳极或阴极tDCS）相关联。也就是说，我们试图确定感觉运动皮层内不同的背景活动水平（阳极：较高活动；阴极：较低活动）是否会产生不同的运动记忆。在一次训练课程后，施加每种tDCS极性会自动导致对应极性的运动记忆被提取。这些结果表明，通过tDCS对感觉运动皮层神经活动进行人工调制可以作为运动记忆形成和回忆的一种背景。
