Skarberg K, Eng M, Huebers H, Marsaglia G, Finch C
Proc Natl Acad Sci U S A. 1978 Mar;75(3):1559-61. doi: 10.1073/pnas.75.3.1559.
The plasma iron turnover was measured in 19 normal subjects. A correlation was found between plasma iron concentration and plasma iron turnover. In addition to the turnover of 55Fe at normal plasma iron concentration (predominantly monoferric transferrin), a second turnover in which the labeled plasma was saturated with iron (to produce predominantly diferric transferrin) was studied with 50Fe. It was demonstrated that diferric transferrin had a greater rate of iron turnover but that the distribution between erythroid and non-erythroid tissues was unchanged. It was concluded that plasma iron turnover is dependent on the monoferric/diferric transferrin ratio in the plasma but that the internal distribution of iron is unaffected.
对19名正常受试者测定了血浆铁周转率。发现血浆铁浓度与血浆铁周转率之间存在相关性。除了在正常血浆铁浓度下（主要是单铁转铁蛋白）的55Fe周转率外，还用50Fe研究了第二个周转率，即标记血浆被铁饱和时（以产生主要是双铁转铁蛋白）的周转率。结果表明，双铁转铁蛋白的铁周转率更高，但红系和非红系组织之间的分布没有变化。得出的结论是，血浆铁周转率取决于血浆中单铁/双铁转铁蛋白的比例，但铁的内部分布不受影响。
